Corley D G, Miller-Wideman M, Durley R C
Monsanto Company, St. Louis, Missouri 63198.
J Nat Prod. 1994 Mar;57(3):422-5. doi: 10.1021/np50105a019.
A new trichothecene, harzianum A [1], was isolated from the soil-borne fungus Trichoderma harzianum. The structure of 1 was determined by extensive spectral analyses including the nmr techniques of PS-COSY, HMQC, HMBC, and NOESY. Harzianum A [1] contains a (Z,E,E)-2,4,6-octatriendioic acid esterified on the 4 beta hydroxyl group of trichodermol and is structurally related to the trichoverroids. Harzianum A [1] showed no cytotoxicity against baby hamster kidney cells, no activity against Gram-negative and Gram-positive bacteria, but modest antifungal activity at 100 micrograms/ml.
一种新的单端孢霉烯族毒素——哈茨木霉A [1]，是从土壤传播的真菌哈茨木霉中分离得到的。通过包括PS-COSY、HMQC、HMBC和NOESY等核磁共振技术在内的广泛光谱分析确定了1的结构。哈茨木霉A [1]在木霉醇的4β羟基上含有一个(Z,E,E)-2,4,6-辛三烯二酸酯，其结构与木霉酸类化合物相关。哈茨木霉A [1]对幼仓鼠肾细胞无细胞毒性，对革兰氏阴性菌和革兰氏阳性菌无活性，但在100微克/毫升时有适度的抗真菌活性。
