Maeda Y, Kawasaki Y, Jibiki I, Yamaguchi N, Matsuda H, Hisada K
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Eur Neurol. 1991;31(6):380-3. doi: 10.1159/000116698.
Changes in brain images with single photon emission computed tomography (SPECT) using 99mTc hexamethylpropyleneamine oxime (HMPAO) before and after therapy with oxygen under high pressure (OHP) were measured in a 66-year-old man with the interval form of carbon monoxide (CO) poisoning by a new technique, i.e., subtraction of brain images. This study was performed 187 days after acute CO poisoning, in a state of chronic akinetic mutism that followed a lucid interval. A diffuse, but frontal-dominant, hypoperfusion pattern involving both the gray and white matter was observed in the pre-OHP SPECT image. After OHP, regional cerebral blood flow increased in both the gray and white matter and markedly increased in the frontal cortical regions. The present finding suggests that OHP is effective against the chronic state of the interval form of CO poisoning.
采用新技术，即脑图像减法，对一名66岁一氧化碳（CO）中毒间歇型患者在高压氧（OHP）治疗前后进行了单光子发射计算机断层扫描（SPECT）脑图像变化测量，该扫描使用99m锝六甲基丙烯胺肟（HMPAO）。本研究在急性CO中毒187天后进行，处于清醒期后的慢性运动不能性缄默状态。在OHP治疗前的SPECT图像中观察到一种弥漫性但以额叶为主的灌注不足模式，累及灰质和白质。OHP治疗后，灰质和白质的局部脑血流量均增加，额叶皮质区域显著增加。目前的研究结果表明，OHP对CO中毒间歇型的慢性状态有效。
