Ford Judith M, Krystal John H, Mathalon Daniel H
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Schizophr Bull. 2007 Jul;33(4):848-52. doi: 10.1093/schbul/sbm062. Epub 2007 Jun 13.
Evidence is accumulating that brain regions communicate with each other in the temporal domain, relying on coincidence of neural activity to detect phasic relationships among neurons and neural assemblies. This coordination between neural populations has been described as "self-organizing," an "emergent property" of neural networks arising from the temporal synchrony between synaptic transmission and firing of distinct neuronal populations. Evidence is also accumulating that communication and coordination failures between different brain regions may account for a wide range of problems in schizophrenia, from psychosis to cognitive dysfunction. We review the knowledge about the functional neuroanatomy and neurochemistry of neural oscillations and oscillation abnormalities in schizophrenia. Based on this, we argue that we can begin to use oscillations, across frequencies, to do translational studies to understand the neural basis of schizophrenia.
越来越多的证据表明，大脑区域在时间域中相互通信，依靠神经活动的同步性来检测神经元和神经集合之间的相位关系。神经群体之间的这种协调被描述为“自组织”，这是神经网络的一种“涌现特性”，源于不同神经元群体的突触传递和放电之间的时间同步。也有越来越多的证据表明，不同脑区之间的通信和协调失败可能是精神分裂症中从精神病到认知功能障碍等一系列问题的原因。我们回顾了关于精神分裂症中神经振荡的功能神经解剖学和神经化学以及振荡异常的知识。基于此，我们认为我们可以开始利用不同频率的振荡进行转化研究，以了解精神分裂症的神经基础。
