Chachich M, Powell D A
Dorn VA Medical Center, Department of Psychology, University of South Carolina, Columbia 29209, USA.
Neurosci Lett. 1998 Dec 4;257(3):151-4. doi: 10.1016/s0304-3940(98)00832-5.
Rabbits with lesions of either medial prefrontal cortex (mPFC) or amygdala central nucleus (ACN) were compared with sham-lesioned animals during differential and reversal classical conditioning of the eyeblink (EB) and heart rate (HR) response. Lesions of the mPFC, but not ACN, produced a severe impairment in EB reversal conditioning, but neither lesion affected original discrimination. However, both mPFC and ACN lesions produced a severe attenuation of accompanying HR decelerations during both initial differentiation and reversal. These results suggest that mPFC processing of Pavlovian conditioning contingencies affects not only the autonomic component of learning but preservative somatomotor conditioning as well, whereas ACN processing affects only the autonomic component.
在眨眼（EB）和心率（HR）反应的辨别性和反转经典条件反射过程中，将内侧前额叶皮质（mPFC）或杏仁核中央核（ACN）有损伤的兔子与假损伤动物进行比较。mPFC损伤而非ACN损伤，在EB反转条件反射中造成了严重损害，但两种损伤均未影响最初的辨别。然而，mPFC和ACN损伤在最初的辨别和反转过程中均导致伴随的HR减速严重减弱。这些结果表明，巴甫洛夫条件反射意外情况的mPFC处理不仅影响学习的自主成分，还影响保存性躯体运动条件反射，而ACN处理仅影响自主成分。
