Ginn S R, Powell D A
Neuroscience Laboratory, Wm. Jennings Bryan Dorn VA Hospital, Columbia, SC 29201.
Exp Brain Res. 1992;89(3):501-10. doi: 10.1007/BF00229874.
Rabbits with lesions of the anterior nucleus basalis of Meynert (nBM) were compared with animals with sham lesions or unoperated control animals on a classical conditioning task in which heart rate (HR) and eyeblink (EB) conditioned responses (CRs) were assessed. The nBM lesions impaired the magnitude of the decelerative HR CR, but had no effect on the EB CR. A second experiment, in which animals were lesioned after acquisition was complete, showed that anterior nBM lesions had no effect on retention of either the HR or EB CR. These data suggest that the anterior nBM may participate in the early stages of information processing in which stimuli are evaluated for their significance based on their association with a reinforcer. However, the anterior nBM is apparently not involved in the selection of a somatomotor response to deal effectively with such changing stimulus contingencies.
将患有迈内特基底前脑核（nBM）损伤的兔子与假损伤动物或未手术的对照动物进行比较，观察它们在一项经典条件反射任务中的表现，该任务评估心率（HR）和眨眼（EB）条件反应（CRs）。nBM损伤削弱了心率减速条件反应的幅度，但对眨眼条件反应没有影响。第二个实验是在动物完成习得后进行损伤，结果表明，前nBM损伤对心率或眨眼条件反应的保持没有影响。这些数据表明，前nBM可能参与信息处理的早期阶段，在这个阶段，根据刺激与强化物的关联来评估刺激的重要性。然而，前nBM显然不参与选择躯体运动反应以有效应对这种不断变化的刺激意外情况。
