Hemingway Harry, Vahtera Jussi, Virtanen Marianna, Pentti Jaana, Kivimäki Mika
International Centre for Health and Society, Department of Epidemiology and Public Health, University College London Medical School, London, UK.
Eur J Cardiovasc Prev Rehabil. 2007 Jun;14(3):373-9. doi: 10.1097/01.hjr.0000230106.01396.a2.
The decline in acute event rates among patients with stable angina emphasizes the need for outcome events that are commonly experienced, externally observed and sensitive to changing functional impairments. In the absence of previous studies, we sought to determine the burden of medically certified spells of sickness absence among individuals with angina and their relation to risk factors and co-morbidity.
A prospective study of 33 148 employees and 1 year experience of medically certified sickness absence in 341 physician-diagnosed angina patients (417 absence spells, total absence days 9733).
Among individuals with angina, sickness absence occurred at a rate of 125 spells per 100 person-years, with age and sex adjusted hazard ratios (compared with their colleagues with no chronic diseases) of 2.90 (95% confidence interval 2.51-3.36), greater than the effect of prolapsed intervertebral disc. Co-morbid diseases were stronger predictors of absence than behavioural risk factors or cardiovascular diseases, and explained 71% of the excess risk of absence in angina.
In a working population, angina has a significant impact on sick leave, largely because of co-morbid diseases. Angina intervention studies that include employed patients should measure, and seek to reverse, this prognostic burden.
稳定型心绞痛患者急性事件发生率的下降凸显了对常见、可外部观察且对功能损害变化敏感的结局事件的需求。在缺乏既往研究的情况下,我们试图确定心绞痛患者经医学认证的病假负担及其与危险因素和合并症的关系。
对33148名员工进行前瞻性研究,并对341名经医生诊断为心绞痛的患者(417次病假,总病假天数9733天)进行为期1年的经医学认证的病假情况调查。
在心绞痛经医学认证的病假发生率为每100人年125次,年龄和性别调整后的风险比(与无慢性病的同事相比)为2.90(95%置信区间2.51-3.36),高于腰椎间盘突出症的影响。合并症比行为危险因素或心血管疾病更能预测病假情况,并且解释了心绞痛患者病假额外风险的71%。
在工作人群中,心绞痛对病假有显著影响,主要是由于合并症。纳入在职患者的心绞痛干预研究应测量并设法扭转这种预后负担。