主动脉和肺动脉的CTA对比增强：在犬类实验模型中以两种不同速率注射生理盐水冲管的效果

CTA contrast enhancement of the aorta and pulmonary artery: the effect of saline chase injected at two different rates in a canine experimental model.

作者信息

Lee Chang Hyun, Goo Jin Mo, Bae Kyongtae T, Lee Hyun Ju, Kim Kwang Gi, Chun Eun Ju, Park Chang Min, Im Jung-Gi

机构信息

Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Jongno-gu, and Seoul National University Hospital, Healthcare Gangnam Center, Gangnam-gu, Seoul, South Korea.

出版信息

Invest Radiol. 2007 Jul;42(7):486-90. doi: 10.1097/RLI.0b013e318032a9fe.

DOI:10.1097/RLI.0b013e318032a9fe

PMID:17568270

Abstract

OBJECTIVE

To investigate the effect of saline chase injected at 2 different rates on computed tomography (CT) angiography.

MATERIALS AND METHODS

This study was approved by our institutional animal study committee. Three injection protocols were used; contrast injection (24 mL, 0.8 mL/s) without saline chase (protocol A), contrast injection with saline chase injected at the same rate as the contrast medium (protocol B), and contrast injection with saline chase injected at half the rate (0.4 mL/s) of the contrast medium (protocol C). In the 3 dogs used in our study, each of the protocols was applied twice for every dog resulting in a total of 18 sessions of monitoring scans. CT images were acquired every second at the fixed level of the aorta and pulmonary artery (PA). The duration of plateau, plateau deviation, and peak arterial enhancement were computed and compared using the Kruskall-Wallis and Mann-Whitney U test.

RESULTS

Peak contrast enhancements were significantly more delayed with protocol B than with protocol A in both the PA (B: 48 seconds, A: 30 seconds, P=0.024) and aorta (B: 46 seconds, A: 38 seconds, P=0.024). The duration of enhancement plateau was longer with protocol B than with protocol A in PA (B: 14.8 seconds, A: 9.0 seconds, P=0.002) and in aorta (B: 16.2 seconds, A: 11.6 seconds, P=0.004). Protocol C had the longest duration of plateau in both PA (34.5 seconds, P=0.002) and aorta (33.8 seconds, P=0.004) with uniform plateau enhancement. The peak enhancement values of protocol C, however, were substantially lower than that of protocol A and B in both the PA (A: 262 HU, B: 239 HU, C: 191 HU, P=0.001) and aorta (A: 263 HU, B: 268 HU, C: 210 HU, P=0.001).

CONCLUSIONS

Saline chase prolongs the duration of plateau and delays peak enhancement of the pulmonary artery and aorta. Saline chase injected at half the rate of contrast medium injection allowed more uniform and prolonged plateau contrast enhancement than other protocols.

摘要

目的

研究以两种不同速率注射生理盐水冲管对计算机断层扫描（CT）血管造影的影响。

材料与方法

本研究经机构动物研究委员会批准。采用了三种注射方案；无生理盐水冲管的造影剂注射（24 mL，0.8 mL/s）（方案A）、以与造影剂相同速率注射生理盐水冲管的造影剂注射（方案B）以及以造影剂一半速率（0.4 mL/s）注射生理盐水冲管的造影剂注射（方案C）。在本研究使用的3只犬中，每种方案对每只犬应用两次，共进行18次监测扫描。每秒在主动脉和肺动脉（PA）的固定层面采集CT图像。使用Kruskal-Wallis和Mann-Whitney U检验计算并比较平台期持续时间、平台期偏差和动脉峰值强化。

结果

在肺动脉（B：48秒，A：30秒，P = 0.024）和主动脉（B：46秒，A：38秒，P = 0.024）中，方案B的峰值造影剂强化均比方案A显著延迟。在肺动脉（B：14.8秒，A：9.0秒，P = 0.002）和主动脉（B：16.2秒，A：11.6秒，P = 0.004）中，方案B的强化平台期持续时间比方案A更长。方案C在肺动脉（34.5秒，P = 0.002）和主动脉（33.8秒，P = 0.004）中的平台期持续时间最长，且平台期强化均匀。然而，方案C在肺动脉（A：262 HU，B：239 HU，C：191 HU，P = 0.001）和主动脉（A：263 HU，B：268 HU，C：210 HU，P = 0.001）中的峰值强化值均显著低于方案A和B。