Department of Radiology, Duke University Medical Center, Erwin Road, Durham, NC 27710, USA.
Eur Radiol. 2011 Sep;21(9):1938-47. doi: 10.1007/s00330-011-2139-x. Epub 2011 May 11.
To prospectively investigate the effect of varying the injection flow rates of a saline chaser on vascular and parenchymal contrast enhancement during abdominal MDCT.
100 consecutive patients were randomly assigned to four injection protocols. A fixed dose of contrast medium was administered followed by no saline (Protocol A) or 50 mL of saline at 2, 4, or 8 mL/s (Protocols B, C, and D). Peak, time-to-peak, and duration of 90% peak enhancement were determined for aorta, pancreas, and liver.
Aortic peak enhancement was significantly higher for Protocol D (369.5 HU) compared with Protocols A and B (332.9 HU and 326.0 HU, respectively; P < 0.05). Pancreatic peak enhancement was significantly higher for Protocols C and D (110.6 HU and 110.9 HU, respectively) compared to Protocol A (92.5 HU; P < 0.05). Aortic and pancreatic time-to-peak enhancement occurred significantly later for Protocol D compared with Protocol A (42.8 s vs. 36.1 s [P < 0.001] and 49.7 s vs. 45.3 s [P = 0.003]).
Injecting a saline chaser at high flow rates yields significantly higher peak aortic and pancreatic enhancement, with a slight longer time-to-peak enhancement.
前瞻性研究在腹部 MDCT 中改变盐水追踪剂注射流速对血管和实质增强的影响。
100 例连续患者被随机分配到四个注射方案。给予固定剂量的造影剂后，不给予生理盐水（方案 A）或以 2、4 或 8mL/s 的速度给予 50mL 生理盐水（方案 B、C 和 D）。测定主动脉、胰腺和肝脏的峰值、达峰时间和 90%峰值增强的持续时间。
与方案 A（332.9 HU 和 326.0 HU）相比，方案 D（369.5 HU）的主动脉峰值增强显著更高（P<0.05）。与方案 A（92.5 HU）相比，方案 C 和 D（110.6 HU 和 110.9 HU）的胰腺峰值增强显著更高（P<0.05）。与方案 A 相比，方案 D 的主动脉和胰腺达峰时间明显延迟（42.8 s 比 36.1 s [P<0.001]和 49.7 s 比 45.3 s [P=0.003]）。
以高流速注射盐水追踪剂可显著提高主动脉和胰腺的峰值增强，达峰时间略有延长。
