Deng Hong, Tang Fang
Department of Traditional Chinese Medicine, General Hospital of Tianjin Medical University, Tianjin (300052).
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26 Suppl:33-5.
To study the effect of Renshen Yangrong decoction (RYD) in protecting morphology and structure of mitochondria in brain and liver of D-galactose induced subacute senile mice.
Forty ICR mice were randomly divided into the youth control group, the model group, the high, middle and low-dose RYD groups. The ultra-structure changes of mitochondria were observed by electronic microscope, the specific surface area, body density, numerical density on area, deltammit area and ridge count of mitochondria were quantitatively analyzed with medical image analyzer.
In the model group, the numbers of mitochondria decreased, mitochondria swelled and significantly expanded, ridge was fragmented, malformed and dissolved even vanished. Those manifestations were coincided with the morphological changes of mitochondria in senile mice. In the different dose of RYD groups, the numbers of mitochondrion increased, mitochondrion tumid were significantly improved, senile degenerative changes of ridge and intima were obviously alleviated in a dose-dependent manner.
RYD can anti-age by improving the changes of mitochondria structure of liver and brain accompanied with ageing.
研究人参养荣汤对D-半乳糖致亚急性衰老小鼠脑和肝脏线粒体形态结构的保护作用。
将40只ICR小鼠随机分为青年对照组、模型组、人参养荣汤高、中、低剂量组。采用电子显微镜观察线粒体超微结构变化，用医学图像分析仪对线粒体的比表面积、体密度、面数密度、线粒体面积和嵴数进行定量分析。
模型组线粒体数量减少，线粒体肿胀并明显扩张，嵴断裂、畸形、溶解甚至消失。这些表现与衰老小鼠线粒体的形态变化一致。在不同剂量人参养荣汤组中，线粒体数量增加，线粒体肿胀明显改善，嵴和内膜的衰老性退变变化呈剂量依赖性明显减轻。
人参养荣汤可通过改善肝脏和脑线粒体结构随衰老的变化而延缓衰老。
