Deng Hong, Tang Fang
Department of Traditional Chinese Medicine, General Hospital of Tianjin Medical University, Tianjin.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26 Suppl:30-3.
To study the effect of Renshen Yangrong decoction (RYD) in protecting membrane fluidity of mitochondrion in brain and liver of D-galactose induced subacute senile mice.
Forty ICR mice were randomly divided into the youth control group, the model group, the high, middle and low-dose RYD groups. The membrane fluidity of mitochondrion in liver and brain cell was measured, and the malondialdehyde (MDA) content of mitochondrion was determined and analyzed.
In the model group, the membrane fluidity of mitochondrion in hepatic and cerebral cells significantly decreased, and the MDA concentration of mitochondrion increased. RYD could significantly reduce the MDA concentration of mitochondrion, markedly increase the membrane fluidity of mitochondrion in a dose-dependent manner.
RYD plays a role in anti-aging through protecting the membrane fluidity of mitochondrion in hepatic and cerebral cells and decreasing the MDA concentration of mitochondrion changing with ageing.
研究人参养荣汤对D-半乳糖致亚急性衰老小鼠脑、肝线粒体膜流动性的保护作用。
将40只ICR小鼠随机分为青年对照组、模型组、人参养荣汤高、中、低剂量组。检测肝和脑细胞线粒体膜流动性，测定并分析线粒体丙二醛（MDA）含量。
模型组肝、脑细胞线粒体膜流动性显著降低，线粒体MDA浓度升高。人参养荣汤可显著降低线粒体MDA浓度，呈剂量依赖性显著提高线粒体膜流动性。
人参养荣汤通过保护肝、脑细胞线粒体膜流动性，降低随衰老而变化的线粒体MDA浓度发挥抗衰老作用。
