Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China.
Chin J Integr Med. 2011 Oct;17(10):770-4. doi: 10.1007/s11655-011-0879-8. Epub 2011 Nov 19.
To explore the anti-fatigue effect of Renshen Yangrong Decoction (RYD): in mice.
One hundred Kunming mice were randomly divided into 5 groups with 20 mice in each: group. The negative control group was treated with distilled water, the positive control group was treated with Shiyiwei Shenqi Tablet (, 1.0 g/kg), the high-, medium- and low-dose RYD groups were treated with 42.0, 21.0 and 10.5 g/kg of RYD daily, respectively, by gastric infusion. At the end of the 7-day treatment, loaded swimming time, organ wet weight and coefficient, serum glucose, urea nitrogen, and hepatic glycogen levels were determined. The outcomes were compared among groups.
As compared with the negative: control group, the loaded swimming time was significantly increased in the positive control group, specifically the medium- and high-dose RYD groups (P<0.01). In addition, the wet weights and coefficients of the spleen and thymus, and the serum glucose and hepatic glycogen contents were increased, whereas serum urea nitrogen level was significantly decreased in the positive control group and the high dose RYD group (P<0.05 or P<0.01).
RYD showed an anti-fatigue effect in mice.
探讨人参养荣汤（RYD）的抗疲劳作用。
将 100 只昆明种小鼠随机分为 5 组，每组 20 只：阴性对照组给予蒸馏水，阳性对照组给予十一味参芪片（，1.0 g/kg），高、中、低剂量 RYD 组分别给予 42.0、21.0 和 10.5 g/kg RYD 灌胃。治疗 7 天后，测定小鼠负重游泳时间、器官湿重及脏器系数、血清葡萄糖、尿素氮和肝糖原水平，并进行组间比较。
与阴性对照组比较，阳性对照组和中、高剂量 RYD 组小鼠的负重游泳时间明显延长（P<0.01）；阳性对照组和高剂量 RYD 组小鼠的脾脏和胸腺湿重及脏器系数、血清葡萄糖和肝糖原含量增加，血清尿素氮含量降低（P<0.05 或 P<0.01）。
RYD 对小鼠具有抗疲劳作用。
