Mohan Viswanathan, Deepa Mohan, Farooq Syed, Narayan K M Venkat, Datta Manjula, Deepa Raj
Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Gopalapuram, Chennai 600 086, India.
Metabolism. 2007 Jul;56(7):961-8. doi: 10.1016/j.metabol.2007.02.009.
The aim of this study was to determine the anthropometric cut points for risk of cardiometabolic risk factors in an urban Asian Indian population. The Chennai Urban Rural Epidemiology Study representatively sampled 26001 individuals aged 20 years or older and detailed measures were obtained in every 10th subject: 90.4% (2350/2600). An oral glucose tolerance test was performed in all individuals except self-reported diabetic subjects. Anthropometric measurements such as body mass index (BMI) and waist circumference (WC) were obtained and serum lipid estimations were done in all subjects. Sensitivity, specificity, and distance on receiver operating characteristic curve were used to determine the optimal cut points for BMI and WC with cardiometabolic risk factors. Maximum sensitivity and specificity of BMI for all cardiometabolic risk factors such as diabetes mellitus, prediabetes, hypertension, hypertriglyceridemia, hypercholesterolemia, and low high-density lipoprotein cholesterol ranged from 22.7 to 23.2 kg/m(2) for men and 22.7 to 23.8 kg/m(2) for women, and that of WC ranged from 86 to 88.2 cm for men and 81 to 83.8 cm for women. The optimal BMI cut point for identifying any 2 cardiometabolic risk factors was 23 kg/m(2) in both sexes, whereas that of WC was 87 cm for men and 82 cm for women. The study validates the World Health Organization Asia Pacific guidelines of BMI of 23 kg/m(2) for the designation of overweight; WC of 87 cm for men and 82 cm for women appear to be appropriate cut points to identify cardiometabolic risk factors including prediabetes in urban Asian Indians.
本研究的目的是确定亚洲印度城市人群中心血管代谢危险因素风险的人体测量切点。金奈城乡流行病学研究对26001名20岁及以上个体进行了代表性抽样，并对每10名受试者中的1名进行了详细测量：90.4%（2350/2600）。除自我报告的糖尿病患者外，所有个体均进行了口服葡萄糖耐量试验。获取了体重指数（BMI）和腰围（WC）等人体测量数据，并对所有受试者进行了血脂测定。利用受试者工作特征曲线上的敏感性、特异性和距离来确定BMI和WC与心血管代谢危险因素的最佳切点。BMI对所有心血管代谢危险因素（如糖尿病、糖尿病前期、高血压、高甘油三酯血症、高胆固醇血症和低高密度脂蛋白胆固醇）的最大敏感性和特异性，男性为22.7至23.2kg/m²，女性为22.7至23.8kg/m²，WC男性为86至88.2cm，女性为81至83.8cm。识别任何两种心血管代谢危险因素的最佳BMI切点，男女均为23kg/m²，而WC男性为87cm，女性为82cm。该研究验证了世界卫生组织亚太地区关于超重的BMI为23kg/m²的指南；男性腰围87cm、女性腰围82cm似乎是识别亚洲印度城市人群中心血管代谢危险因素（包括糖尿病前期）的合适切点。
