Jo Su Kyoung, Kim Hyun Soo, Cho Sung Whan, Seo Sang Heui
Laboratory of Influenza Research, Institute of Veterinary Medicine, Chungnam National University, Yuseong-Gu, Daejeon 305-764, South Korea.
Virus Res. 2007 Oct;129(1):64-70. doi: 10.1016/j.virusres.2007.05.005. Epub 2007 Jun 14.
Swine influenza viruses are an important pathogen in pig industry. In this study, we wanted to know whether swine H1N2 influenza viruses circulating in Korean pigs would cause clinical signs in pigs when experimentally infected. When pigs were infected with swine H1N2 viruses isolated from Korean pigs, pigs suffered from severe clinical signs of coughing, nasal discharge, labored breathing, facial edema, anorexia, and diarrhea. When the level of cytokine induction was measured using lung tissues, pro-inflammatory cytokines such as TNF-alpha, IL-1, and IL-8 were induced higher in lungs of infected pigs than in lungs of uninfected pigs. However, no increased induction of the anti-inflammatory cytokines such as IL-4 and IL-10 was observed in lungs of infected pigs. These results suggest that the pathogenesis induced in pigs by H1N2 influenza viruses may be induced by pro-inflammatory cytokines instead of anti-inflammatory cytokines.
猪流感病毒是养猪业中的一种重要病原体。在本研究中，我们想了解在韩国猪群中传播的猪H1N2流感病毒在实验感染时是否会使猪出现临床症状。当猪感染从韩国猪分离出的猪H1N2病毒时，猪出现了咳嗽、流鼻涕、呼吸困难、面部水肿、厌食和腹泻等严重临床症状。当使用肺组织测量细胞因子诱导水平时，感染猪肺中促炎细胞因子如TNF-α、IL-1和IL-8的诱导水平高于未感染猪的肺。然而，在感染猪的肺中未观察到抗炎细胞因子如IL-4和IL-10的诱导增加。这些结果表明，H1N2流感病毒在猪中诱导的发病机制可能是由促炎细胞因子而非抗炎细胞因子引起的。
