Clavin M, Gorzalczany S, Macho A, Muñoz E, Ferraro G, Acevedo C, Martino V
Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina.
J Ethnopharmacol. 2007 Jul 25;112(3):585-9. doi: 10.1016/j.jep.2007.04.007. Epub 2007 Apr 24.
Three anti-inflammatory compounds: nepetin, jaceosidin and hispidulin have been isolated and identified from Eupatorium arnottianum Griseb. dichloromethane extract. Nepetin reduced the TPA mouse ear edema by 46.9% and jaceosidin by 23.2% (1mg/ear). Both compounds inhibited the NF kappaB induction by 91 and 77%, respectively. Furthermore phytochemical analysis of the ethanol extract has led to the identification of eriodictyol, hyperoside, rutin, caffeic and chlorogenic acids. All these compounds are reported for the first time in this species. The finding of topical antiinflammatory activity exerted by Eupatorium arnottianum extract and the identification of active principles could support the use of this plant for the treatment of inflammatory affections.
从阿诺特泽兰（Eupatorium arnottianum Griseb.）的二氯甲烷提取物中分离并鉴定出了三种抗炎化合物：橙皮素、香叶木素和滨蓟黄苷。橙皮素使TPA诱导的小鼠耳肿胀减轻了46.9%，香叶木素使肿胀减轻了23.2%（1毫克/耳）。这两种化合物分别抑制NF-κB的诱导达91%和77%。此外，对乙醇提取物的植物化学分析还鉴定出了圣草酚、金丝桃苷、芦丁、咖啡酸和绿原酸。所有这些化合物均首次在该物种中被报道。阿诺特泽兰提取物具有局部抗炎活性以及活性成分的鉴定结果，可为该植物用于治疗炎症性疾病提供支持。
