Yang Chun-Yuh, Chen Chien-Juan
Faculty of Public Health, College of Health Sciences, Kaohsiung Medical University, 100 Shih-Chuan 1st RD, Kaohsiung, Taiwan.
J Toxicol Environ Health A. 2007 Jul;70(14):1214-9. doi: 10.1080/15287390701380880.
This study was undertaken to determine whether there was an association between air pollutant levels and hospital admissions for chronic obstructive pulmonary disease (COPD) in Taipei, Taiwan. Hospital admissions for COPD and ambient air pollution data for Taipei were obtained for the period 1996-2003. The relative risk of hospital admission was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single-pollutant model, on warm days (> or = 20 degrees C) statistically significant positive associations were found in all pollutants except sulphur dioxide (SO2). However, statistically significant effects for COPD admissions on cool days (< 20 degrees C) were observed only for SO2 levels. For the two-pollutant model, NO2 and O3 were significant in combination with each of the other four pollutants on warm days. This study provides evidence that higher levels of ambient air pollutants increases the risk of hospital admissions for COPD in Taiwan.
本研究旨在确定台湾台北市空气污染物水平与慢性阻塞性肺疾病(COPD)住院率之间是否存在关联。获取了1996 - 2003年期间台北市COPD住院情况及环境空气污染数据。采用病例交叉法估计住院的相对风险,并对天气变量、星期几、季节性和长期时间趋势进行控制。在单污染物模型中,在温暖的日子(≥20摄氏度),除二氧化硫(SO2)外,所有污染物均发现有统计学显著的正相关。然而,仅在凉爽的日子(<20摄氏度),SO2水平对COPD住院有统计学显著影响。在双污染物模型中,在温暖的日子,二氧化氮(NO2)和臭氧(O3)与其他四种污染物中的每一种结合时均具有显著性。本研究提供了证据表明较高水平的环境空气污染物会增加台湾COPD住院风险。