破坏干细胞生态位：良莠并存。

Disrupting the stem cell niche: good seeds in bad soil.

作者信息

Perry John M, Li Linheng

机构信息

Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.

出版信息

Cell. 2007 Jun 15;129(6):1045-7. doi: 10.1016/j.cell.2007.05.053.

DOI:10.1016/j.cell.2007.05.053

PMID:17574018

Abstract

Stem cells reside in a microenvironment or niche that is critical for stem cell maintenance and regulation. But what happens when a stem cell niche is disrupted? In this issue of Cell, two reports (Walkley et al., 2007a, 2007b) demonstrate in mice that alterations in the niche for hematopoietic stem cells lead to the development of myeloproliferative disease.

摘要

干细胞存在于对干细胞维持和调节至关重要的微环境或生态位中。但是，当干细胞生态位被破坏时会发生什么呢？在本期《细胞》杂志中，两篇报告（沃克利等人，2007年a版，2007年b版）在小鼠中证明，造血干细胞生态位的改变会导致骨髓增殖性疾病的发展。