Carey Michelle A, Card Jeffrey W, Voltz James W, Germolec Dori R, Korach Kenneth S, Zeldin Darryl C
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L272-8. doi: 10.1152/ajplung.00174.2007. Epub 2007 Jun 15.
Numerous animal studies have revealed significant effects of sex and sex hormones on normal lung development, lung physiology, and various lung diseases. The primary goal of this review is to summarize knowledge to date on the effects of sex and sex hormones on lung development, physiology, and disease in animals. Specific emphasis will be placed on fibrosis, allergic airway disease, acute lung injury models, respiratory infection, and lung toxicology studies.
众多动物研究已揭示性别和性激素对正常肺发育、肺生理学以及各种肺部疾病有显著影响。本综述的主要目的是总结目前关于性别和性激素对动物肺发育、生理学及疾病影响的知识。将特别着重于纤维化、变应性气道疾病、急性肺损伤模型、呼吸道感染及肺毒理学研究。
