Jalali M, Bayat A
Department of Plastic and Reconstructive Surgery, South Manchester University Hospitals Trust.
Surgeon. 2007 Jun;5(3):175-80. doi: 10.1016/s1479-666x(07)80045-x.
Scars are a natural part of dermal healing processes and consist of networks of fibrous collagen tissue, laid down in response to injury to the dermis. In some genetically susceptible individuals, the process of scar tissue formation is excessive, and there is an over-secretion of collagen. This causes the formation of benign tumours (raised) scars known as keloid and hypertrophic scars. Scars can have many significant functional, cosmetic and psychological sequelae. Steroids are used therapeutically in the management of abnormal scars; however, this is associated with a variety of adverse effects. Their intralesional administration is the most widely used and most effective treatment modality for raised skin scars today. Despite this, our understanding of the way in which they work is poor and literature on the topic is, to date, lacking. Further work is needed to clarify the exact mechanisms that bring about abnormal scarring, to aid our understanding of the disease and facilitate the development of more evidence-based treatment strategies.
疤痕是皮肤愈合过程的自然组成部分，由纤维状胶原组织网络构成，是真皮受伤后的反应产物。在一些具有遗传易感性的个体中，疤痕组织形成过程过度，胶原蛋白分泌过多。这会导致形成良性肿瘤（隆起）疤痕，即瘢痕疙瘩和增生性疤痕。疤痕会产生许多严重的功能、美容和心理后遗症。类固醇在异常疤痕的治疗中被用作药物；然而，这会带来多种不良反应。它们的皮损内给药是目前治疗皮肤隆起疤痕最广泛使用且最有效的治疗方式。尽管如此，我们对其作用方式的了解甚少，迄今为止，关于该主题的文献也很缺乏。需要进一步开展工作，以阐明导致异常疤痕形成的确切机制，帮助我们了解这种疾病，并促进制定更具循证依据的治疗策略。
