Lee M R
Clinical Pharmacology and Therapeutics, University of Edinburgh, Edinburgh, Scotland.
J R Coll Physicians Edinb. 2007 Mar;37(1):77-84.
The Deadly Nightshade, Atropa belladonna, is a plant surrounded by myth, fear and awe. In antiquity, the Greeks and the Romans knew that it contained a deadly poison. In medieval times, it was widely used by witches, sorcerors and professional poisoners. Linnaeus later codified its remarkable properties as the genus Atropa, the Fate that slits the thin spun life and the species belladonna because of its power to dilate the pupils. In the 1830s, the pure alkaloid I-atropine was isolated from the plant. This proved to be a significant tool in the study of the autonomic nervous system leading to the identification of acetylcholine as an important neurotransmitter in mammals. When pure atropine became available, it caused a large number of deaths, whether by accident, suicide or homicide.
颠茄,即阿托ropa belladonna,是一种笼罩在神话、恐惧与敬畏之中的植物。在古代,希腊人和罗马人就知道它含有致命毒药。中世纪时,女巫、巫师和职业投毒者广泛使用它。后来,林奈将其显著特性编纂为阿托ropa属,即剪断脆弱生命之线的命运女神,以及颠茄种,因其具有扩张瞳孔的能力。19世纪30年代,从该植物中分离出了纯生物碱l-阿托品。这被证明是研究自主神经系统的一项重要工具,从而导致乙酰胆碱被确认为哺乳动物中的一种重要神经递质。当纯阿托品可得时,它导致了大量死亡,无论是意外、自杀还是他杀。