Giladi N, Huber-Mahlin V, Herman T, Hausdorff J M
Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
J Neural Transm (Vienna). 2007;114(10):1349-53. doi: 10.1007/s00702-007-0772-y. Epub 2007 Jun 18.
Freezing of gait (FOG) is frequently observed in high level gait disorders (HLGD), but its relationship to disease progression and cognitive function is unknown. To study this relationship, episodic gait disturbances, affect and cognitive function were assessed in twenty-five patients with HLGD (mean age: 78.2 +/- 5.0 yrs). After a mean of 32.2 +/- 4.2 months, twenty-two patients were reassessed. FOG was observed in 20% of the patients at baseline and in 40% at follow-up. The presence of FOG was associated with significant mobility disturbances, functional deterioration as well as poor performance on the frontal neuropsychological assessment battery (Dementia Rating Scale - initiation sub-score) at follow-up. Depression, anxiety and fear of falling were not correlated with the presence of FOG at baseline or follow-up. These results indicate that FOG is common in HLGD, and that it is associated with significant functional disability and a specific frontal cognitive disturbance of initiation.
冻结步态（FOG）在高级步态障碍（HLGD）中经常出现，但其与疾病进展及认知功能的关系尚不清楚。为研究这种关系，对25例HLGD患者（平均年龄：78.2±5.0岁）的发作性步态障碍、情感及认知功能进行了评估。平均32.2±4.2个月后，对22例患者进行了重新评估。基线时20%的患者出现FOG，随访时为40%。随访时，FOG的存在与显著的活动障碍、功能恶化以及额叶神经心理评估量表（痴呆评定量表 - 启动子量表）表现不佳相关。抑郁、焦虑和跌倒恐惧与基线或随访时FOG的存在无关。这些结果表明，FOG在HLGD中很常见，并且与显著的功能残疾和特定的额叶启动认知障碍相关。
