迷迭香酸在日本脑炎实验小鼠模型中的抗病毒和抗炎作用
Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis.
作者信息
Swarup Vivek, Ghosh Joydeep, Ghosh Soumya, Saxena Amit, Basu Anirban
机构信息
National Brain Research Centre, Manesar, Haryana-122050, India.
出版信息
Antimicrob Agents Chemother. 2007 Sep;51(9):3367-70. doi: 10.1128/AAC.00041-07. Epub 2007 Jun 18.
Abstract
Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 days postinfection.
摘要
迷迭香酸（RA）降低了感染日本脑炎病毒（JEV）小鼠的死亡率。在感染后8至9天，与未接受治疗的感染小鼠相比，用RA治疗的JEV感染动物的病毒载量（P < 0.001）和促炎细胞因子水平（P < 0.001）显著降低。
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