Nardelli Andrea, Carbonez An, Ottoy Winfried, Drieghe Jacques, Goossens An
Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium.
Contact Dermatitis. 2008 Mar;58(3):134-41. doi: 10.1111/j.1600-0536.2007.01287.x.
The widespread use of fragrance-containing products is probably the most important reason for its high impact in allergic contact dermatitis.
To describe the frequency of contact allergy to fragrance allergens as tested in the standard series, in relation to age, sex and lesion locations. To determine trends in frequency over the years and to study the association between positive tests observed with the different fragrance-allergy markers as well as between specific fragrance allergens and locations of the lesions.
PATIENTS/METHODS: 10 128 patients underwent patch testing between January 1990 and December 2005 at the Dermatology department in Leuven.
1463 (14.5%), that is, 380 (26%) males and 1083 (74%) females, reacted positively to at least 1 fragrance-allergy marker in the standard series: 9% to fragrance mix I, 6% to Myroxylon pereirae, and 4.8% to colophonium (often in association), 2.1% to hydroxyisohexyl 3-cyclohexene carboxaldehyde and 2.1% to fragrance mix II, the latter 2 allergens having been introduced more recently. Over the years, fragrance contact allergy has shown a fluctuating trend. Hands and face were the most commonly affected body sites. Moreover, a significant association was found between specific fragrance allergens and certain locations.
This study illustrates that fragrance contact allergy is common in patients suffering from contact dermatitis.
含香料产品的广泛使用可能是其在过敏性接触性皮炎中影响巨大的最重要原因。
描述在标准系列测试中，与年龄、性别和皮损部位相关的香料变应原接触过敏的频率。确定多年来频率的变化趋势，并研究不同香料过敏标志物阳性测试之间以及特定香料变应原与皮损部位之间的关联。
患者/方法：1990年1月至2005年12月期间，10128例患者在鲁汶皮肤科接受了斑贴试验。
1463例（14.5%）患者，即380例（26%）男性和1083例（74%）女性，对标准系列中至少1种香料过敏标志物反应呈阳性：对香料混合物Ⅰ过敏的占9%，对秘鲁香脂过敏的占6%，对松香（常合并出现）过敏的占4.8%，对羟基异己基3 - 环己烯甲醛过敏的占2.1%，对香料混合物Ⅱ过敏的占2.1%，后两种变应原是最近才引入的。多年来，香料接触过敏呈波动趋势。手部和面部是最常受累的身体部位。此外，还发现特定香料变应原与某些部位之间存在显著关联。
本研究表明，香料接触过敏在接触性皮炎患者中很常见。
