Thyssen Jacob P, Carlsen Berit Christina, Menné Torkil, Johansen Jeanne Duus
Department of Dermatology, National Allergy Research Centre, Gentofte University Hospital, Ledreborg Allé 40, 1. 2820 Gentofte, Denmark.
Contact Dermatitis. 2008 Oct;59(4):238-44. doi: 10.1111/j.1600-0536.2008.01418.x.
Fragrance contact allergy has for long been recognized as an important health issue. In Denmark, the frequency of fragrance mix (FM) I contact allergy increased between 1985-1986 and 1997-1998 among male and female dermatitis patients.
To investigate the development of FM I and Myroxylon pereirae (MP) contact allergy between 1985 and 2007 with an emphasis on recent years.
A retrospective analysis of all patch test data from our database was performed. Comparison of sensitivity rates was made using a chi-squared test for trend. Logistic regression analyses were used to test for associations.
Of 16,173 patients, 7.2% were sensitized to FM I and 4% to MP. FM I contact allergy was associated with female sex [odds ratio (OR) = 1.52; 95% confidence interval (CI) = 1.33-1.74] and age between 41 and 60 years (OR = 3.20; 95% CI = 1.98-5.21). Significant declines of FM I and MP reactions among women but not men were observed between 1999 and 2007.
Although the frequency of FM I contact allergy has decreased in Denmark in recent years, it is still high. Furthermore, fragrance contact allergy is caused by other important allergens not included in this analysis. Allergic contact reactions to the ingredients of FM I remain a problem in European consumers.
香料接触性过敏长期以来一直被认为是一个重要的健康问题。在丹麦，1985 - 1986年至1997 - 1998年间，男性和女性皮炎患者中香料混合物（FM）I接触性过敏的发生率有所上升。
调查1985年至2007年间FM I和秘鲁胶（MP）接触性过敏的发展情况，重点关注近年来的情况。
对我们数据库中所有斑贴试验数据进行回顾性分析。使用趋势卡方检验比较敏感率。采用逻辑回归分析来检验关联性。
在16173名患者中，7.2%对FM I致敏，4%对MP致敏。FM I接触性过敏与女性性别相关[比值比（OR）= 1.52；95%置信区间（CI）= 1.33 - 1.74]以及41至60岁的年龄相关（OR = 3.20；95% CI = 1.98 - 5.·21）。1999年至2007年间，观察到女性中FM I和MP反应显著下降，而男性中未出现这种情况。
尽管近年来丹麦FM I接触性过敏的发生率有所下降，但仍然很高。此外，香料接触性过敏是由本分析未包括的其他重要过敏原引起的。对FM I成分的过敏性接触反应在欧洲消费者中仍然是一个问题。
