Ciocoiu Manuela, Badescu Magda M, Lupusoru Elena C
Department of Pathophysiology, University of Medicine and Pharmacy, Iasi, Romania.
Free Radic Res. 2007 Jul;41(7):829-38. doi: 10.1080/10715760701416434.
During effort overstress the reactive oxygen species act chiefly on unsaturated lipids, inducing the formation of certain peroxidation products. We have investigated malondialdehide (MDA), platelet adhesion index, and immunological activation parameters during effort overstress and administration of vitamins E and C. Biochemical measurements were performed on erythrocytes and heart homogenate. In the vitamin E supplemented group, the platelet adhesion index was constantly correlated with the MDA level (p < 0.001). There is a protecting effect concerning the oxidative stress in animals pretreated with vitamin E and C, which is expressed through the diminution of the MDA quantity both in the erythrocyte and in the heart. The physical effort required by swimming led to a decrease in the NBT test values and in the activity of the serum complement. The steady administration of vitamin E in the effort overstress, due to its antioxidant properties, causes the progressive decrease in peroxidation and platelet adhesion.
在运动过度应激期间，活性氧主要作用于不饱和脂质，诱导某些过氧化产物的形成。我们研究了运动过度应激以及维生素E和C给药期间的丙二醛（MDA）、血小板黏附指数和免疫激活参数。对红细胞和心脏匀浆进行了生化检测。在补充维生素E的组中，血小板黏附指数与MDA水平持续相关（p < 0.001）。维生素E和C预处理的动物对氧化应激有保护作用，这通过红细胞和心脏中MDA量的减少来体现。游泳所需的体力活动导致硝基蓝四唑试验值和血清补体活性降低。在运动过度应激期间持续给予维生素E，由于其抗氧化特性，会导致过氧化和血小板黏附逐渐减少。
