Lambert Joshua D, Kwon Seok-Joo, Hong Jungil, Yang Chung S
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA.
Free Radic Res. 2007 Jul;41(7):850-3. doi: 10.1080/10715760601091659.
Tea (Camellia sinensis) catechins have been studied for disease prevention. These compounds undergo oxidation and produce H(2)O(2). We have previously shown that holding tea solution or chewing tea leaves generates high salivary catechin levels. Herein, we examined the generation of H(2)O(2) in the oral cavity by green tea solution or leaves. Human volunteers holding green tea solution (0.1-0.6%) developed salivary H(2)O(2) with C(max) = 2.9-9.6 microM and AUC(0 --> infinity) = 8.5-285.3 microM min. Chewing 2 g green tea leaves produced higher levels of H(2)O(2) (C(max) = 31.2 microM, AUC(0 --> infinity) = 1290.9 microM min). Salivary H(2)O(2) correlated with catechin levels and with predicted levels of H(2)O(2) (C(max(expected)) = 36 microM vs C(max(determined)) = 31.2 microM). Salivary H(2)O(2) and catechin concentrations were similar to those that are biologically active in vitro. Catechin-generated H(2)O(2) may, therefore, have a role in disease prevention by green tea.
茶（茶树）儿茶素已被研究用于疾病预防。这些化合物会发生氧化并产生过氧化氢。我们之前已经表明，含漱茶溶液或咀嚼茶叶会使唾液中的儿茶素水平升高。在此，我们研究了绿茶溶液或茶叶在口腔中产生过氧化氢的情况。含漱绿茶溶液（0.1 - 0.6%）的人类志愿者唾液中产生了过氧化氢，Cmax = 2.9 - 9.6微摩尔/升，AUC(0 --> ∞) = 8.5 - 285.3微摩尔·分钟。咀嚼2克绿茶茶叶产生的过氧化氢水平更高（Cmax = 31.2微摩尔/升，AUC(0 --> ∞) = 1290.9微摩尔·分钟）。唾液中的过氧化氢与儿茶素水平以及预测的过氧化氢水平相关（Cmax(expected) = 36微摩尔/升，vs Cmax(determined) = 31.2微摩尔/升）。唾液中的过氧化氢和儿茶素浓度与体外具有生物活性的浓度相似。因此，儿茶素产生的过氧化氢可能在绿茶预防疾病中发挥作用。
