真菌中的聚酮化合物、蛋白质和基因：程序化纳米机器开始揭示其奥秘。
Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets.
作者信息
Cox Russell J
机构信息
School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK BS8 1TS.
出版信息
Org Biomol Chem. 2007 Jul 7;5(13):2010-26. doi: 10.1039/b704420h. Epub 2007 May 10.
Fungi produce a wide variety of biologically active compounds. Among these, the polyketides form a large and structurally diverse group. These compounds are synthesised by highly programmed and very large iterative multifunctional proteins, the polyketide synthases, with nm dimensions. This review outlines the current state of knowledge regarding the links between gene sequence, protein architecture and biosynthetic programming for fungal polyketide synthases.
真菌能产生各种各样的生物活性化合物。其中，聚酮化合物构成了一个庞大且结构多样的类别。这些化合物由高度程序化且非常大的迭代多功能蛋白质——聚酮合酶合成，其尺寸达纳米级。本综述概述了关于真菌聚酮合酶的基因序列、蛋白质结构和生物合成程序之间联系的当前知识状态。
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