Faber R, Trimble M R
Department of Psychiatry, University of Texas Health Science Center, San Antonio.
Mov Disord. 1991;6(4):293-303. doi: 10.1002/mds.870060405.
Early case reports note marked improvements in the signs of Parkinson's disease (PD) in several patients with coexisting psychiatric disorders after treatment with electroconvulsive therapy (ECT). Studies since 1959 reveal improvement of parkinsonism in over half of PD patients receiving ECT, regardless of the presence or absence of psychiatric comorbidity. Drug-induced parkinsonism, tardive dystonia, and tardive dyskinesia have also been shown to improve with ECT administration; tic syndromes have achieved mixed results. In animals, ECT enhances dopamine-mediated effects and increases GABA concentrations in the CNS. Optimal parameters relevant to the antiparkinsonism effects of ECT require further study.
早期病例报告指出，电休克治疗（ECT）后，数名同时患有精神疾病的帕金森病（PD）患者的帕金森病体征有显著改善。自1959年以来的研究表明，超过半数接受ECT治疗的PD患者的帕金森症状有所改善，无论是否存在精神疾病合并症。药物性帕金森综合征、迟发性肌张力障碍和迟发性运动障碍在接受ECT治疗后也有所改善；抽动综合征的治疗效果不一。在动物实验中，ECT可增强多巴胺介导的效应，并增加中枢神经系统中的γ-氨基丁酸（GABA）浓度。与ECT抗帕金森病作用相关的最佳参数有待进一步研究。
