Ishihara Junko, Otani Tetsuya, Inoue Manami, Iwasaki Motoki, Sasazuki Shizuka, Tsugane Shoichiro
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
J Nutr. 2007 Jul;137(7):1808-14. doi: 10.1093/jn/137.7.1808.
We investigated the association of dietary intakes of folate, vitamin B-6, vitamin B-12, and methionine with the risk of colorectal cancer in a large prospective cohort study of middle-aged Japanese men and women. A total of 81,184 subjects (38,107 men and 43,077 women) who participated in the Japan Public Health Center-based Prospective Study were followed from 1995-1998 to the end of 2002, during which 526 cases of colorectal cancer (335 men, 191 women) were newly identified. Dietary intake of nutrients was calculated using a 138-item self-administered FFQ. We observed a significant inverse association between vitamin B-6 intake and colorectal cancer in men. Compared with the lowest quartile, the multivariate hazard ratio (95% [CI]) in the highest quartile of intake was 0.69 (0.48-0.98) (P(trend) = 0.03). Men who consumed 150 g/wk alcohol or more had twice the risk of colorectal cancer of those who drank less in the lowest quartile of vitamin B-6 intake, but risk due to alcohol intake was not higher in the highest quartile of vitamin B-6 intake. Vitamin B-6 intake and colorectal cancer were not associated in women. Folate and methionine intakes were not associated with colorectal cancer risk in men or women, but colorectal cancer risk tended to increase (P(trend) = 0.05) with increasing intake of vitamin B-12 in men. Our results support previous evidence that low vitamin B-6 intake is associated with an increased risk of colorectal cancer. In particular, a higher intake of vitamin B-6 appears beneficial in men with higher alcohol intake.
在一项针对日本中年男性和女性的大型前瞻性队列研究中，我们调查了叶酸、维生素B-6、维生素B-12和蛋氨酸的膳食摄入量与结直肠癌风险之间的关联。共有81184名受试者（38107名男性和43077名女性）参与了基于日本公共卫生中心的前瞻性研究，从1995年至1998年一直随访至2002年底，在此期间新确诊了526例结直肠癌病例（335名男性，191名女性）。使用一份包含138个条目的自填式食物频率问卷计算营养素的膳食摄入量。我们观察到男性维生素B-6摄入量与结直肠癌之间存在显著的负相关。与摄入量最低的四分位数相比，摄入量最高的四分位数的多因素风险比（95%[CI]）为0.69（0.48 - 0.98）（P趋势 = 0.03）。在维生素B-6摄入量最低的四分位数中，每周饮酒150克或更多的男性患结直肠癌的风险是饮酒较少者的两倍，但在维生素B-6摄入量最高的四分位数中，酒精摄入导致的风险并不更高。女性中维生素B-6摄入量与结直肠癌无关联。叶酸和蛋氨酸摄入量与男性或女性的结直肠癌风险均无关联，但男性中结直肠癌风险随维生素B-12摄入量增加有升高趋势（P趋势 = 0.05）。我们的结果支持了先前的证据，即低维生素B-6摄入量与结直肠癌风险增加有关。特别是，较高的维生素B-6摄入量对酒精摄入量较高的男性似乎有益。
