Centre of Research and Promotion of Women's Health, 4th Floor, School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin NT, Hong Kong Special Administrative Region, People's Republic of China.
Br J Nutr. 2011 Sep;106(6):936-43. doi: 10.1017/S0007114511001140. Epub 2011 May 16.
Few studies have evaluated the relationship between the consumption of dietary folate and one-carbon metabolism-related nutrients and breast cancer risk defined by oestrogen receptor (ER) and progesterone receptor (PR) status. The objective of the present study was to examine the associations between dietary folate, vitamin B6, vitamin B12, and methionine intake and the risk of breast cancer by ER and PR status among Chinese women in Guangdong. A hospital-based case-control study was conducted from June 2007 to August 2008, with 438 cases and 438 age (5-year interval)- and residence (rural/urban)-matched controls. Dietary intake information was assessed using a validated FFQ administered through a face-to-face interview. Unconditional logistic regression models were used to calculate multivariate-adjusted OR and 95 % CI. A significant inverse association was found between dietary folate and vitamin B6 intake and breast cancer risk. The adjusted OR of the highest v. the lowest quartile were 0·32 (95 % CI 0·21, 0·49; P(trend) < 0·001) for dietary folate and 0·46 (95 % CI 0·30, 0·69; P(trend) < 0·001) for vitamin B6. No associations were observed for vitamin B12 and methionine intake. A significant inverse association between dietary folate intake and breast cancer risk was observed in all subtypes of ER and PR status. These findings suggest that dietary folate and vitamin B6 intakes were inversely associated with breast cancer risk. The inverse association did not differ by ER and/or PR status.
很少有研究评估膳食叶酸和与雌激素受体 (ER) 和孕激素受体 (PR) 状态定义的乳腺癌风险相关的一碳代谢营养素之间的关系。本研究的目的是研究广东女性中膳食叶酸、维生素 B6、维生素 B12 和蛋氨酸摄入与 ER 和 PR 状态乳腺癌风险之间的关系。2007 年 6 月至 2008 年 8 月进行了一项基于医院的病例对照研究，共纳入 438 例病例和 438 名年龄（5 岁间隔）和居住地（农村/城市）匹配的对照。通过面对面访谈使用经过验证的 FFQ 评估膳食摄入信息。使用无条件逻辑回归模型计算多变量调整后的 OR 和 95 % CI。膳食叶酸和维生素 B6 摄入量与乳腺癌风险呈显著负相关。最高四分位 v. 最低四分位的调整后 OR 分别为 0·32（95 % CI 0·21，0·49；P(trend) < 0·001），膳食叶酸和 0·46（95 % CI 0·30，0·69；P(trend) < 0·001)。维生素 B12 和蛋氨酸摄入与乳腺癌风险无关。在所有 ER 和 PR 状态亚型中，膳食叶酸摄入量与乳腺癌风险呈显著负相关。这些发现表明，膳食叶酸和维生素 B6 摄入与乳腺癌风险呈负相关。这种负相关与 ER 和/或 PR 状态无关。
