Stark J M, Fatemi S H, Amini S B, Huang Y T
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106.
Pediatr Pulmonol. 1991;11(2):98-102. doi: 10.1002/ppul.1950110204.
In order to determine the frequency of occurrence of the two respiratory syncytial virus (RSV) subtypes in hospitalized children in Cleveland, Ohio, we analyzed clinical isolates obtained during three consecutive winter epidemic seasons between 1985 and 1988. RSV was recovered from the frozen clinical specimens of 197 patients: 176 subtype A, and 21 subtype B. Subtype A predominated during all three epidemic seasons, ranging from 83 to 94% of isolates. We surveyed the clinical records of 16 children with subtype B, and 101 children with subtype A infections, hospitalized at the University Hospitals of Cleveland during these winter epidemics and found no differences in age, sex, race, or clinical spectrum of severity of disease caused by the two subtypes. In contrast to previously reported data, subtype A predominated in each of the winter seasons studied within this community. We conclude that both subtypes circulate concurrently within the community during the winter. In hospitalized children both subtypes appear to cause a similar spectrum of disease. Both the concurrent circulation of RSV subtypes and the similar spectrum of illness pose for important considerations in the development of effective vaccines against this common respiratory agent in children.
为了确定俄亥俄州克利夫兰市住院儿童中两种呼吸道合胞病毒（RSV）亚型的出现频率，我们分析了1985年至1988年连续三个冬季流行季节期间获得的临床分离株。从197例患者的冷冻临床标本中分离出RSV：176例为A亚型，21例为B亚型。在所有三个流行季节中，A亚型均占主导地位，占分离株的83%至94%。我们调查了在这些冬季流行期间于克利夫兰大学医院住院的16例B亚型感染儿童和101例A亚型感染儿童的临床记录，发现这两种亚型在年龄、性别、种族或所引起疾病严重程度的临床谱方面没有差异。与先前报道的数据相反，在该社区研究的每个冬季季节中，A亚型均占主导地位。我们得出结论，在冬季这两种亚型在社区中同时传播。在住院儿童中，这两种亚型似乎引起相似的疾病谱。RSV亚型的同时传播以及相似的疾病谱是开发针对这种常见儿童呼吸道病原体的有效疫苗时的重要考虑因素。
