Lazar Alexander J F, Trent Jonathan C, Lev Dina
Department of Pathology and Sarcoma Research Center, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA.
Curr Oncol Rep. 2007 Jul;9(4):309-15. doi: 10.1007/s11912-007-0038-8.
Methodologies employed in the rapidly developing field of soft tissue sarcoma molecular testing focus primarily on diagnosis using chromosomal translocations and the resulting fusion transcripts. Molecular prognostic testing holds promise in this complex group of rare mesenchymal malignancies, but results are preliminary and require further confirmation. Analysis of activating KIT mutations in gastrointestinal stromal tumors is currently being used in management of patient therapy.
软组织肉瘤分子检测这一快速发展领域中所采用的方法主要聚焦于利用染色体易位及由此产生的融合转录本进行诊断。分子预后检测在这类复杂的罕见间叶性恶性肿瘤中具有前景，但结果尚属初步，需要进一步证实。目前，胃肠道间质瘤中激活型KIT突变的分析已用于患者治疗的管理。
