中年男性体内的内源性睾酮与血脂
Endogenous testosterone and serum lipids in middle-aged men.
作者信息
Mäkinen Juuso I, Perheentupa Antti, Irjala Kerttu, Pöllänen Pasi, Mäkinen Juha, Huhtaniemi Ilpo, Raitakari Olli T
机构信息
Department of Clinical Physiology, University of Turku, FIN-20520 Turku, Finland.
出版信息
Atherosclerosis. 2008 Apr;197(2):688-93. doi: 10.1016/j.atherosclerosis.2007.05.009. Epub 2007 Jun 22.
BACKGROUND
The role of decreasing testosterone levels influencing lipid metabolism in aging men is not well established.
METHODS
We studied 1619 40 to 69-year old men with andropausal symptoms, who underwent measurements of serum testosterone, triglycerides, total-, and HDL-cholesterol.
RESULTS
Testosterone (mean 15.25 nmol/l+/-5.43 S.D., range 3.6-45.0 nmol/l) correlated directly with HDL-cholesterol (r=0.24, p<0.0001) and inversely with total cholesterol (r=-0.06, p<0.03), triglycerides (r=-0.30, p<0.0001) and body mass index (r=-0.34, p<0.0001), but not with LDL-cholesterol (r=0.05, p=0.09). In multivariate analyses adjusted for age, body mass index, smoking, alcohol consumption, diabetes and cardiovascular diseases, the significant determinants for serum triglycerides were testosterone (beta=-0.03, p<0.0001), age (beta=-0.01, p<0.0001), body mass index (beta=0.039, p<0.0001) and cardiovascular diseases (beta=0.09, p<0.04). The multivariate correlates of HDL-cholesterol included testosterone (beta=0.007, p<0.0001), body mass index (beta=-0.02, p<0.0001) and alcohol consumption (beta=0.02, p<0.0001).
CONCLUSIONS
We conclude that in aging men low testosterone levels are associated with a potentially atherogenic lipid profile including high triglycerides and low HDL-cholesterol.
背景
睾酮水平降低对老年男性脂质代谢的影响尚不明确。
方法
我们研究了1619名年龄在40至69岁之间有更年期症状的男性，对他们进行了血清睾酮、甘油三酯、总胆固醇和高密度脂蛋白胆固醇的检测。
结果
睾酮（均值15.25纳摩尔/升±5.43标准差，范围3.6 - 45.0纳摩尔/升）与高密度脂蛋白胆固醇呈正相关（r = 0.24，p < 0.0001），与总胆固醇呈负相关（r = -0.06，p < 0.03），与甘油三酯呈负相关（r = -0.30，p < 0.0001），与体重指数呈负相关（r = -0.34，p < 0.0001），但与低密度脂蛋白胆固醇无相关性（r = 0.05，p = 0.09）。在对年龄、体重指数、吸烟、饮酒、糖尿病和心血管疾病进行校正的多因素分析中，血清甘油三酯的显著决定因素为睾酮（β = -0.03，p < 0.0001）、年龄（β = -0.01，p < 0.0001）、体重指数（β = 0.039，p < 0.0001）和心血管疾病（β = 0.09，p < 0.04）。高密度脂蛋白胆固醇的多因素相关因素包括睾酮（β = 0.007，p < 0.0001）、体重指数（β = -0.02，p < 0.0001）和饮酒（β = 0.02，p < 0.0001）。
结论
我们得出结论，在老年男性中，低睾酮水平与包括高甘油三酯和低高密度脂蛋白胆固醇在内的潜在致动脉粥样硬化脂质谱相关。
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