Department of Health Sciences, Jan Długosz University in Częstochowa, 42-200 Częstochowa, Poland.
Urological and Andrological Clinic "Urogen", 42-600 Tarnowskie Góry, Poland.
Nutrients. 2020 Dec 30;13(1):113. doi: 10.3390/nu13010113.
The aim of this study was to determine whether, after 8 days of water-only fasting, there are changes in the efficiency of the lower urinary tract, the concentration of sex hormones, and the symptoms of prostate diseases in a group of middle-aged men ( = 14). For this purpose, before and after 8 days of water-only fasting (subjects drank moderately mineralized water), and the following somatic and blood concentration measurements were made: total prostate specific antigen (PSA-T), free prostate specific antigen (PSA-F), follicle stimulating hormone (FSH), luteotropic hormone (LH), prolactin (Pr), total testosterone (T-T), free testosterone (T-F), dehydroepiandrosterone (DHEA), sex hormone globulin binding (SHGB), total cholesterol (Ch-T), β-hydroxybutyrate (β-HB). In addition, prostate volume (PV), volume of each testis (TV), total volume of both testes (TTV), maximal urinary flow rate (Qmax), and International Prostate Symptom Score (IPSS) values were determined. The results showed that after 8 days of water-only fasting, Qmax and IPSS improved but PV and TTV decreased significantly. There was also a decrease in blood levels of PSA-T, FSH, P, T-T, T-F, and DHEA, but SHGB concentration increased significantly. These results indicate that 8 days of water-only fasting improved lower urinary tract functions without negative health effects.
本研究旨在确定在 8 天仅饮水禁食后，一组中年男性（n=14）的下尿路效率、性激素浓度和前列腺疾病症状是否会发生变化。为此，在 8 天仅饮水禁食（受试者适度饮用矿泉水）前后进行了以下体测量和血液浓度测量：总前列腺特异性抗原（PSA-T）、游离前列腺特异性抗原（PSA-F）、卵泡刺激素（FSH）、促黄体生成素（LH）、催乳素（Pr）、总睾酮（T-T）、游离睾酮（T-F）、脱氢表雄酮（DHEA）、性激素球蛋白结合（SHGB）、总胆固醇（Ch-T）、β-羟丁酸（β-HB）。此外，还测定了前列腺体积（PV）、每个睾丸体积（TV）、两个睾丸的总体积（TTV）、最大尿流率（Qmax）和国际前列腺症状评分（IPSS）值。结果表明，仅饮水禁食 8 天后，Qmax 和 IPSS 得到改善，但 PV 和 TTV 显著下降。血液中 PSA-T、FSH、P、T-T、T-F 和 DHEA 水平下降，而 SHGB 浓度显著升高。这些结果表明，8 天仅饮水禁食可改善下尿路功能，而不会对健康产生负面影响。
