Torres Sandra Regina, Peixoto Camila Bernardo, Caldas Daniele Manhães, Akiti Tiyomi, Barreiros Maria Glória Carvalho, de Uzeda Milton, Nucci Marcio
Department of Oral Pathology and Diagnosis, School of Dentistry, Federal University of Rio de Janeiro.
Braz Oral Res. 2007 Apr-Jun;21(2):182-7. doi: 10.1590/s1806-83242007000200015.
Low salivary flow rates are associated with higher oral Candida spp. counts, which may predispose to oral candidiasis. The aim of this study was to compare the effect of stimulating salivary flow rates with that of a regimen of chlorhexidine mouth rinse on the intensity of Candida colonization in patients with reduced salivary flow rates. Thirty-one outpatients were randomized to stimulate salivary output (group 1) or to receive chlorhexidine mouth rinses (group 2). Evaluations were performed at baseline (T0), at end of treatment (T1), and 15 days after last day of treatment (T2). Chewing-stimulated whole saliva samples were collected at each visit. Group 1 showed a constant reduction in median cfu counts, although the difference was significant only between T0 and T2 (p = 0.004). Group 2 showed a reduction in median Candida cfu counts between T0 and T1 (p = 0.01), but the counts increased at T2 (p = 0.01), and the difference between T0 and T2 was not significant (p = 0.8). In conclusion, patients who received salivary stimulation showed reductions of Candida cfu counts in saliva and a trend for increasing salivary flow rates between baseline and end of study evaluations. The use of chlorhexidine mouth rinses dramatically reduced Candida cfu counts, but when patients discontinued treatment, intensity of colonization rose again.
唾液流速低与口腔念珠菌属计数较高有关，这可能易引发口腔念珠菌病。本研究的目的是比较刺激唾液流速与洗必泰漱口水方案对唾液流速降低患者念珠菌定植强度的影响。31名门诊患者被随机分为刺激唾液分泌组（第1组）或接受洗必泰漱口水组（第2组）。在基线期（T0）、治疗结束时（T1）以及治疗最后一天后的15天（T2）进行评估。每次就诊时收集咀嚼刺激后的全唾液样本。第1组的菌落形成单位（cfu）中位数持续下降，尽管仅在T0和T2之间差异有统计学意义（p = 0.004）。第2组在T0和T1之间念珠菌cfu中位数下降（p = 0.01），但在T2时计数增加（p = 0.01），且T0和T2之间的差异无统计学意义（p = 0.8）。总之，接受唾液刺激的患者唾液中念珠菌cfu计数减少，且在基线和研究评估结束之间唾液流速有增加趋势。使用洗必泰漱口水显著降低了念珠菌cfu计数，但当患者停止治疗时，定植强度再次上升。
