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本文引用的文献

1
Relative sensitivity of soluble guanylate cyclase and mitochondrial respiration to endogenous nitric oxide at physiological oxygen concentration.在生理氧浓度下，可溶性鸟苷酸环化酶和线粒体呼吸对内源性一氧化氮的相对敏感性。
Biochem J. 2007 Jul 15;405(2):223-31. doi: 10.1042/BJ20070033.
2
Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration.脱氧肌红蛋白是一种亚硝酸盐还原酶，可生成一氧化氮并调节线粒体呼吸。
Circ Res. 2007 Mar 16;100(5):654-61. doi: 10.1161/01.RES.0000260171.52224.6b. Epub 2007 Feb 9.
3
Nitric oxide and peroxynitrite in health and disease.一氧化氮与过氧亚硝酸盐在健康与疾病中的作用
Physiol Rev. 2007 Jan;87(1):315-424. doi: 10.1152/physrev.00029.2006.
4
Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics.解析一氧化氮、亚硝酸盐和血红蛋白在生理学及治疗学中的反应。
Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):697-705. doi: 10.1161/01.ATV.0000204350.44226.9a. Epub 2006 Jan 19.
5
Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response.一氧化氮：通过线粒体呼吸和内质网应激反应协调缺氧调节
Cell Res. 2005 Jan;15(1):63-5. doi: 10.1038/sj.cr.7290267.
6
Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway.氮氧代谢异常：一氧化氮-细胞色素c氧化酶信号通路功能障碍的病理后果。
Free Radic Biol Med. 2005 Feb 1;38(3):297-306. doi: 10.1016/j.freeradbiomed.2004.10.037.
7
The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice.诱导型一氧化氮合酶在小鼠酒精性肝毒性和线粒体功能障碍中的作用。
Hepatology. 2004 Sep;40(3):565-73. doi: 10.1002/hep.20326.
8
Control of mitochondrial respiration by NO*, effects of low oxygen and respiratory state.一氧化氮对线粒体呼吸的调控、低氧的影响及呼吸状态
J Biol Chem. 2003 Aug 22;278(34):31603-9. doi: 10.1074/jbc.M211784200. Epub 2003 Jun 4.
9
Differential sensitivity of guanylyl cyclase and mitochondrial respiration to nitric oxide measured using clamped concentrations.使用钳制浓度测量鸟苷酸环化酶和线粒体呼吸对一氧化氮的差异敏感性。
J Biol Chem. 2002 Aug 30;277(35):31801-7. doi: 10.1074/jbc.M205936200. Epub 2002 Jun 21.
10
Does nitric oxide modulate mitochondrial energy generation and apoptosis?一氧化氮是否调节线粒体能量生成和细胞凋亡？
Nat Rev Mol Cell Biol. 2002 Mar;3(3):214-20. doi: 10.1038/nrm762.

氧气作为可溶性鸟苷酸环化酶和细胞色素c氧化酶对一氧化氮反应性的主要调节因子的证据。

Evidence for oxygen as the master regulator of the responsiveness of soluble guanylate cyclase and cytochrome c oxidase to nitric oxide.

作者信息

Landar Aimee, Darley-Usmar Victor M

机构信息

Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

出版信息

Biochem J. 2007 Jul 15;405(2):e3-4. doi: 10.1042/bj20070590.

DOI:10.1042/bj20070590
PMID:17590153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1904518/
Abstract

Haem is used as a versatile receptor for redox active molecules; most notably NO (nitric oxide) and oxygen. Three haem-containing proteins, myoglobin, haemoglobin and cytochrome c oxidase, are now known to bind NO, and in all these cases competition with oxygen plays an important role in the biological outcome. NO also binds to the haem group of sGC (soluble guanylate cyclase) and initiates signal transduction through the formation of cGMP in a process that is oxygen-independent. From biochemical studies, it has been shown that sGC is substantially more sensitive to NO than is cytochrome c oxidase, but a direct comparison in a cellular setting under various oxygen levels has not been reported previously. In this issue of the Biochemical Journal, Cadenas and co-workers reveal how oxygen can act as the master regulator of the relative sensitivity of the cytochrome c oxidase and sGC signalling pathways to NO. These findings have important implications for our understanding of the interplay between NO and oxygen in both physiology and the pathology of diseases associated with hypoxia.

摘要

血红素作为一种对氧化还原活性分子具有多种功能的受体；最显著的是一氧化氮（NO）和氧气。目前已知三种含血红素的蛋白质，即肌红蛋白、血红蛋白和细胞色素c氧化酶，都能结合NO，在所有这些情况下，与氧气的竞争在生物学结果中起着重要作用。NO还能与可溶性鸟苷酸环化酶（sGC）的血红素基团结合，并通过在一个不依赖氧气的过程中形成环鸟苷酸（cGMP）来启动信号转导。从生化研究中可以看出，sGC对NO的敏感性远高于细胞色素c氧化酶，但此前尚未有在不同氧气水平的细胞环境中进行直接比较的报道。在本期《生物化学杂志》中，卡德纳斯及其同事揭示了氧气如何作为细胞色素c氧化酶和sGC信号通路对NO相对敏感性的主要调节因子。这些发现对于我们理解NO与氧气在生理学以及与缺氧相关疾病病理学中的相互作用具有重要意义。