Clewell Don B
Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, MI 48109-1078, USA.
Plasmid. 2007 Nov;58(3):205-27. doi: 10.1016/j.plasmid.2007.05.001. Epub 2007 Jun 27.
The 60-kb pAD1 represents a large and widely disseminated family of conjugative, pheromone-responding, virulence plasmids commonly found in clinical isolates of Enterococcus faecalis. It encodes a hemolysin/bacteriocin (cytolysin) shown to contribute to virulence in animal models, and the related bacteriocin is active against a wide variety of Gram-positive bacteria. This review summarizes what is currently known about the molecular biology of pAD1, including aspects of its cytolytic, UV-resistance, replication, maintenance, and conjugative properties.
60千碱基对的pAD1代表了一个庞大且广泛传播的接合型、信息素应答型、毒力质粒家族，常见于粪肠球菌的临床分离株中。它编码一种溶血素/细菌素（细胞溶素），已证明该溶血素/细菌素在动物模型中有助于毒力，并且相关细菌素对多种革兰氏阳性菌具有活性。本综述总结了目前关于pAD1分子生物学的已知信息，包括其细胞溶解、抗紫外线、复制、维持和接合特性等方面。
Zotero 插件