Iber C, O'Brien C, Schluter J, Davies S, Leatherman J, Mahowald M
Minnesota Regional Sleep Disorders Center, Minneapolis.
Sleep. 1991 Oct;14(5):383-5.
The role of single night studies and the determinants of effective nasal continuous positive airway (CPAP) pressures were determined in 412 consecutive patients between 1984 and 1989. Patients chosen for analysis had an apnea index (AI) of greater than or equal to 20 hr-1 prior to CPAP. The AI was 67 +/- 30 hr-1, the body mass index (BMI) was 36 +/- 9 kg/m2, the age was 51 +/- 13 yr and the lowest oxygen saturation was 72 +/- 14%. Effective CPAP (9 +/- 3 cm H2O) was documented in 320 patients on single night studies and resulted in a 99% reduction in the frequency of obstructive events and improvement in the lowest O2 saturation to 94 +/- 5%. Only 18% of the variability in effective CPAP could be explained by AI and BMI. Single night studies are sufficient to establish effective CPAP in 78% of patients and offer considerable conservation of resources compared to routine multiple night studies. Effective CPAP pressures are variable and must be determined by incremental CPAP trials.
1984年至1989年间，对412例连续患者进行了单夜研究，以确定其作用及有效鼻持续气道正压通气（CPAP）压力的决定因素。入选分析的患者在接受CPAP治疗前的呼吸暂停指数（AI）大于或等于20次/小时。AI为67±30次/小时，体重指数（BMI）为36±9kg/m²，年龄为51±13岁，最低血氧饱和度为72±14%。单夜研究记录了320例患者的有效CPAP（9±3cmH₂O），阻塞性事件频率降低了99%，最低血氧饱和度提高到94±5%。有效CPAP中只有18%的变异性可由AI和BMI解释。单夜研究足以确定78%患者的有效CPAP，与常规多夜研究相比，可节省大量资源。有效CPAP压力各不相同，必须通过递增CPAP试验来确定。
