Aguglia Eugenio, Pascolo-Fabrici Elisabetta, Bertossi Francesca, Bassi Mariano
Psychiatric Clinic of the University of Trieste, Via Paolo De Ralli 5, 34126, Trieste, Italy.
Clin Pract Epidemiol Ment Health. 2007 Jun 25;3:7. doi: 10.1186/1745-0179-3-7.
The lack of compliance is associated with an increased risk of hospitalization and switching or augmentation of therapy when compared with being compliant. A synergy of drug therapy and psychosocial interventions can give more benefits in treatment.
A perspective study was conducted on 150 patients with schizophrenia over 15 centers in Italy. The experimental group was treated with drug therapy, traditional psychosocial and psychoeducation for the patients and their families, while the control group received traditional psychosocial and drug intervention over 1 year.
The experimental group showed a significant statistical improvement (p < 0,05) in almost all the scales that have been assessed (BPRS, SAPS, SANS, SIMPSON-ANGUS SCALE, LANCASHIRE QL SCALE). Significant was the reduction of the number of hospitalizations and of days of hospital stay.
As it is shown in international literature, psychoeducational intervention with schizophrenic patients and their families can reduce the occurrence of relapse.
与依从性良好相比，缺乏依从性与住院风险增加以及治疗转换或强化相关。药物治疗与心理社会干预的协同作用在治疗中能带来更多益处。
在意大利15个中心对150例精神分裂症患者进行了一项前瞻性研究。实验组接受药物治疗、针对患者及其家属的传统心理社会干预和心理教育，而对照组在1年时间内接受传统心理社会干预和药物干预。
实验组在几乎所有评估量表（BPRS、SAPS、SANS、SIMPSON-ANGUS量表、LANCASHIRE QL量表）上均显示出显著的统计学改善（p < 0.05）。住院次数和住院天数显著减少。
正如国际文献所示，对精神分裂症患者及其家属进行心理教育干预可减少复发的发生。
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