Ozben Tomris
Department of Biochemistry, Medical Faculty, Akdeniz University, 07070 Antalya, Turkey.
J Pharm Sci. 2007 Sep;96(9):2181-96. doi: 10.1002/jps.20874.
It is well established that some chemotherapeutic agents and radiation therapy generate reactive oxygen species (ROS) in patients during cancer therapy. Free radicals, particularly ROS have been proposed as common mediators for apoptosis. Recent studies have demonstrated that the mode of cell death depends on the severity of the oxidative damage. This review will address some of the current paradigms of oxidative stress, and antioxidants on apoptosis, and discuss the potential mechanisms by which oxidants can regulate apoptotic pathways. It will also review new developments in eliminating cancer cells by selectively inducing apoptosis.
众所周知，一些化疗药物和放射疗法在癌症治疗期间会在患者体内产生活性氧（ROS）。自由基，特别是ROS，已被认为是细胞凋亡的常见介质。最近的研究表明，细胞死亡的模式取决于氧化损伤的严重程度。本综述将阐述氧化应激和抗氧化剂对细胞凋亡的一些当前范式，并讨论氧化剂调节凋亡途径的潜在机制。它还将综述通过选择性诱导细胞凋亡来消除癌细胞的新进展。
