Meagher Mary W, Johnson Robin R, Vichaya Elisabeth Good, Young Erin E, Lunt Shannon, Welsh C Jane
Texas A&M University, Department of Psychology, USA.
Trauma Violence Abuse. 2007 Jul;8(3):314-30. doi: 10.1177/1524838007303506.
A growing body of evidence suggests that social conflict is associated with inflammatory disease onset and exacerbations in multiple sclerosis (MS) patients and in animal models of MS. This review illustrates how animal research can be used to elucidate the biobehavioral mechanisms underlying the adverse health effects of social conflict. The authors review studies indicating that social conflict exacerbates a virally initiated animal model of MS. This research suggests that the deleterious effects of social conflict may be partially mediated by stress-induced increases in pro-inflammatory cytokine levels in the central nervous system. In addition, they provide evidence that the adverse health effects of social conflict can be prevented by blocking the stress-induced increases in cytokine activity. This suggests that interventions designed to prevent or reverse the stress-induced increases in cytokine activity may be able to prevent or reverse some of the negative health effects of social conflict in humans.
越来越多的证据表明，社会冲突与多发性硬化症（MS）患者以及MS动物模型中炎症性疾病的发作和加重有关。这篇综述阐述了如何利用动物研究来阐明社会冲突对健康产生不利影响的生物行为机制。作者回顾了表明社会冲突会加剧MS病毒引发动物模型病情的研究。这项研究表明，社会冲突的有害影响可能部分是由压力诱导的中枢神经系统促炎细胞因子水平升高介导的。此外，他们提供证据表明，通过阻断压力诱导的细胞因子活性增加，可以预防社会冲突对健康的不利影响。这表明，旨在预防或逆转压力诱导的细胞因子活性增加的干预措施可能能够预防或逆转人类社会冲突的一些负面健康影响。
