Herbrig Erdmuth, Sandner Dirk, Engelmann Katrin
Department of Ophthalmology, Universitatsklinikum Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany.
Ophthalmic Res. 2007;39(4):198-206. doi: 10.1159/000104681. Epub 2007 Jun 26.
High-density silicone oils are newly developed long-term tamponade agents for the treatment of complicated retinal detachment in the inferior retina. Previous studies describe satisfying anatomical and functional results. In this study we examined the largest cohort so far for a 9-month follow-up and performed a comparison to conventional silicone oil.
Our study documents results and adverse effects after vitreoretinal surgery and endotamponade with Densiron 68 in 99 cases of complicated retinal detachment. A 9-month follow-up was performed. Data of 21 patients with intraocular conventional silicone oil tamponade in complicated retinal detachment were retrospectively analyzed and served as control.
Anatomical success was achieved in 78 of 89 eyes (87.6%) with completed follow-up; visual acuity did not change significantly (from mean preoperative logMAR 1.88 to postoperative logMAR 1.96 (p = 0.9). Compared to control a higher anatomical success but a similar number of adverse effects were observed with heavy silicone oil in vitreous. Nevertheless, patients who received Densiron 68 twice due to redetachment showed a significantly higher rate of intraocular inflammation with the tamponade agent in situ.
Our results support the hypothesis of Densiron 68 as potent tamponade agent for complicated retinal detachment in the inferior retinal segments especially in eyes where a previous operation failed.
高密度硅油是新开发的用于治疗视网膜下象限复杂视网膜脱离的长效填塞剂。既往研究描述了令人满意的解剖和功能结果。在本研究中，我们对迄今为止最大的队列进行了9个月的随访，并与传统硅油进行了比较。
我们的研究记录了99例复杂视网膜脱离患者行玻璃体视网膜手术及用Densiron 68进行眼内填塞后的结果和不良反应。进行了9个月的随访。对21例复杂视网膜脱离行眼内传统硅油填塞患者的数据进行回顾性分析并作为对照。
89只完成随访的眼中，78只（87.6%）获得了解剖学成功；视力无显著变化（术前平均logMAR 1.88，术后logMAR 1.96（p = 0.9））。与对照组相比，玻璃体腔使用重硅油观察到更高的解剖学成功率，但不良反应数量相似。然而，因视网膜再次脱离而接受两次Densiron 68治疗的患者，眼内填塞剂原位时眼内炎症发生率显著更高。
我们的结果支持Densiron 68作为视网膜下象限复杂视网膜脱离有效填塞剂的假设，尤其是在既往手术失败的眼中。
