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1540纳米铒玻璃激光治疗炎性面部痤疮的评估

Evaluation of the 1,540-nm Erbium:Glass Laser in the Treatment of Inflammatory Facial Acne.

作者信息

Bogle Melissa A, Dover Jeffrey S, Arndt Kenneth A, Mordon Serge

机构信息

The Laser and Cosmetic Surgery Center of Houston, Houston, Texas, and SkinCare Physicians, Chestnut Hill, Massachusetts, USA.

出版信息

Dermatol Surg. 2007 Jul;33(7):810-7. doi: 10.1111/j.1524-4725.2007.33174.x.

Abstract

BACKGROUND

The erbium:glass laser is approved to treat inflammatory acne on the back.

OBJECTIVE

This aim of this study was to evaluate the use of the 1,540-nm erbium:glass laser in the treatment of moderate to severe inflammatory acne on the face.

METHODS AND MATERIALS

An erbium:glass laser (Aramis, Quantel Medical, Clermont-Ferrand, France) was used to treat 15 patients with moderate to severe acne four times at 2-week intervals. Active lesions were first treated with six pulses at 10 J/cm(2). The entire face was then treated with a single pass using bursts of four pulses at 10 J/cm(2). Sebum measurements were performed. Six patients continued in a double-arm study to determine whether an additional treatment at 6 months would prolong the lesion-free period. Final evaluation was at 9 months. RESULTS At 6-month follow-up, patients rated improvement as 68%, and the mean investigator improvement assessment was 78%. Sebum measurements did not change. No patients required anesthesia, and no side effects were observed. A single retreatment session 6 months after the initial course held clearance at 80% at 9-month follow-up, whereas patients without retreatment had 72% clearance.

CONCLUSION

Treatment of inflammatory facial acne with the 1,540-nm erbium:glass laser is effective and relatively painless. Papules, pustules, and nodules all respond well to therapy. Additional treatment sessions may prolong the lesion-free period, and maintenance therapy should be included as a part of the treatment course.

摘要

背景

铒玻璃激光已被批准用于治疗背部的炎性痤疮。

目的

本研究旨在评估1540纳米铒玻璃激光对面部中度至重度炎性痤疮的治疗效果。

方法和材料

使用铒玻璃激光(法国克莱蒙费朗Quantel Medical公司的Aramis)对15例中度至重度痤疮患者进行治疗,每隔2周治疗4次。首先以10 J/cm²的能量对活动性皮损进行6次脉冲治疗。然后以10 J/cm²的能量,每次4个脉冲为一组,对面部进行单次扫描治疗。进行皮脂测量。6例患者继续参与双臂研究,以确定6个月时的额外治疗是否会延长无皮损期。最终评估在9个月时进行。结果:在6个月的随访中,患者自我评估的改善率为68%,研究者评估的平均改善率为78%。皮脂测量结果无变化。所有患者均无需麻醉,未观察到副作用。在初始疗程6个月后进行单次再治疗的患者,在9个月随访时的皮损清除率为80%,而未进行再治疗的患者皮损清除率为72%。

结论

1540纳米铒玻璃激光治疗面部炎性痤疮有效且相对无痛。丘疹、脓疱和结节对该治疗均反应良好。额外的治疗疗程可能会延长无皮损期,维持治疗应作为治疗过程的一部分。

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