Akinci B, Bayraktar F, Saklamaz A, Demir T, Yener S, Comlekci A, Ozcan M A, Kebapcilar L, Yuksel F, Yesil S
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University Medical School, 35340 Inciralti, Izmir, Turkey.
J Endocrinol Invest. 2007 May;30(5):350-5. doi: 10.1007/BF03346309.
Although the etiology of osteoporosis is different between men and women, the underlying pathophysiological mechanism is similar, namely an absolute or relative increase in bone resorption, leading to progressive bone loss. Transforming growth factor (TGF)-beta1 is a growth factor in human bone, which is produced by osteoblasts, and which has various effects on osteoclasts and osteoblasts. The aim of our study was to determine serum TGF-beta1 levels in male patients with idiopathic osteoporosis.
Twenty five males with idiopathic osteoporosis and 25 age-matched controls were studied. Osteoporosis was defined by a T score of <-2.5 in the lumbar spine or at the femoral neck. We measured levels of TGF-beta1, estradiol, total and bioactive testosterone. Various markers of bone remodeling were also measured.
TGF-beta1 was significantly lower in osteoporotic patients than in controls (3.706 ng/dl, 25-75 percentiles: 2.81-5.33 vs 8.659 ng/dl, 25-75 percentiles: 4.837-11.835; p=0.000). Moreover, TGF-beta1 levels were positively correlated with bone mineral density (BMD) at the femoral neck (r=0.439, p=0.028), and at the lumbar spine (r=0.41, p=0.042). No correlation was found between serum estradiol, testosterone and TGF-beta1 levels.
Serum TGF-beta1 levels are depressed in osteoporotic men and are positively correlated with hip and spine BMD. The results of our study suggest that TGF-beta1 may play a role in the pathogenesis of idiopathic male osteoporosis.
尽管男性和女性骨质疏松症的病因不同，但其潜在的病理生理机制相似，即骨吸收的绝对或相对增加，导致进行性骨质流失。转化生长因子（TGF）-β1是人体骨骼中的一种生长因子，由成骨细胞产生，对破骨细胞和成骨细胞有多种作用。我们研究的目的是测定特发性骨质疏松男性患者的血清TGF-β1水平。
研究了25例特发性骨质疏松男性患者和25例年龄匹配的对照者。骨质疏松症的定义为腰椎或股骨颈的T值<-2.5。我们测量了TGF-β1、雌二醇、总睾酮和生物活性睾酮水平。还测量了各种骨重塑标志物。
骨质疏松患者的TGF-β1水平显著低于对照组（3.706 ng/dl，25-75百分位数：2.81-5.33 vs 8.659 ng/dl，25-75百分位数：4.837-11.835；p=0.000）。此外，TGF-β1水平与股骨颈骨密度（BMD）呈正相关（r=0.439，p=0.028），与腰椎骨密度也呈正相关（r=0.41，p=0.042）。血清雌二醇、睾酮和TGF-β1水平之间未发现相关性。
骨质疏松男性患者的血清TGF-β1水平降低，且与髋部和脊柱骨密度呈正相关。我们的研究结果表明，TGF-β1可能在特发性男性骨质疏松症发病机制中起作用。
