细胞磁共振成像：用于无创细胞定位的纳米和微米尺寸颗粒
Cellular magnetic resonance imaging: nanometer and micrometer size particles for noninvasive cell localization.
作者信息
Slotkin Jonathan R, Cahill Kevin S, Tharin Suzanne A, Shapiro Erik M
机构信息
Department of Neurosurgery, The Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Neurotherapeutics. 2007 Jul;4(3):428-33. doi: 10.1016/j.nurt.2007.05.010.
Abstract
The use of nanometer and micrometer-sized superparamagnetic iron oxide particles as cellular contrast agents allows for the noninvasive detection of labeled cells on high-resolution magnetic resonance images. The development and application of these techniques to neurologic disorders is likely to accelerate the development of cell transplantation therapies and allow for the detailed study of in vivo cellular biology. This review summarizes the early development of iron oxide-based cellular contrast agents and the more recent application of this technology to noninvasive imaging of cellular transplants. The ability of this technique to allow for the noninvasive detection of in vivo transplants on the single-cell level is highlighted.
摘要
使用纳米和微米级超顺磁性氧化铁颗粒作为细胞造影剂，能够在高分辨率磁共振图像上对标记细胞进行无创检测。这些技术在神经系统疾病中的开发与应用，可能会加速细胞移植疗法的发展，并有助于对体内细胞生物学进行详细研究。本综述总结了基于氧化铁的细胞造影剂的早期发展情况，以及该技术在细胞移植无创成像方面的最新应用。重点介绍了该技术在单细胞水平上对体内移植进行无创检测的能力。
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本文引用的文献
1
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Nat Med. 2007 Apr;13(4):498-503. doi: 10.1038/nm1497. Epub 2007 Mar 11.
2
Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brain.成年啮齿动物大脑中生成的神经前体细胞迁移的磁共振成像。
Neuroimage. 2006 Sep;32(3):1150-7. doi: 10.1016/j.neuroimage.2006.04.219. Epub 2006 Jun 30.
3
In vivo detection of single cells by MRI.通过磁共振成像对体内单细胞进行检测。
Magn Reson Med. 2006 Feb;55(2):242-9. doi: 10.1002/mrm.20718.
4
In vivo magnetic resonance imaging of single cells in mouse brain with optical validation.小鼠大脑单细胞的体内磁共振成像及光学验证
Magn Reson Med. 2006 Jan;55(1):23-9. doi: 10.1002/mrm.20747.
5
A new transgene reporter for in vivo magnetic resonance imaging.一种用于体内磁共振成像的新型转基因报告基因。
Nat Med. 2005 Apr;11(4):450-4. doi: 10.1038/nm1208. Epub 2005 Mar 20.
6
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7
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Transplantation. 2004 Dec 15;78(11):1626-33. doi: 10.1097/01.tp.0000145528.51525.8b.
8
MRI of transplanted pancreatic islets.移植胰岛的磁共振成像
Magn Reson Med. 2004 Dec;52(6):1228-33. doi: 10.1002/mrm.20282.
9
Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS.超顺磁性氧化铁标记的雪旺细胞和嗅鞘细胞可通过磁共振成像在体内进行追踪，并且在移植到中枢神经系统后仍保留功能特性。
J Neurosci. 2004 Nov 3;24(44):9799-810. doi: 10.1523/JNEUROSCI.3126-04.2004.
10
MRI detection of single particles for cellular imaging.用于细胞成像的单颗粒的磁共振成像检测
Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10901-6. doi: 10.1073/pnas.0403918101. Epub 2004 Jul 15.
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