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铁核-碳壳纳米颗粒作为先进的磁共振成像造影剂

Fe Core-Carbon Shell Nanoparticles as Advanced MRI Contrast Enhancer.

作者信息

Chaudhary Rakesh P, Kangasniemi Kim, Takahashi Masaya, Mohanty Samarendra K, Koymen Ali R

机构信息

Department of Physics, University of Texas at Arlington; Arlington, TX 76019, USA.

Advanced Imaging Research Center, Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

J Funct Biomater. 2017 Oct 9;8(4):46. doi: 10.3390/jfb8040046.

DOI:10.3390/jfb8040046
PMID:28991207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5748553/
Abstract

The aim of this study is to fabricate a hybrid composite of iron (Fe) core-carbon (C) shell nanoparticles with enhanced magnetic properties for contrast enhancement in magnetic resonance imaging (MRI). These new classes of magnetic core-shell nanoparticles are synthesized using a one-step top-down approach through the electric plasma discharge generated in the cavitation field in organic solvents by an ultrasonic horn. Transmission electron microscopy (TEM) observations revealed the core-shell nanoparticles with 10-85 nm in diameter with excellent dispersibility in water without any agglomeration. TEM showed the structural confirmation of Fe nanoparticles with body centered cubic (bcc) crystal structure. Magnetic multi-functional hybrid composites of Fe core-C shell nanoparticles were then evaluated as negative MRI contrast agents, displaying remarkably high transverse relaxivity (₂) of 70 mM·S at 7 T. This simple one-step synthesis procedure is highly versatile and produces desired nanoparticles with high efficacy as MRI contrast agents and potential utility in other biomedical applications.

摘要

本研究的目的是制备具有增强磁性的铁（Fe）核-碳（C）壳纳米颗粒的混合复合材料，用于磁共振成像（MRI）中的对比度增强。这些新型磁核壳纳米颗粒是通过一步自上而下的方法合成的，该方法利用超声换能器在有机溶剂的空化场中产生的电等离子体放电来实现。透射电子显微镜（TEM）观察显示，核壳纳米颗粒的直径为10-85nm，在水中具有优异的分散性，无任何团聚现象。TEM显示了具有体心立方（bcc）晶体结构的Fe纳米颗粒的结构确认。然后，对Fe核-C壳纳米颗粒的磁性多功能混合复合材料作为阴性MRI造影剂进行了评估，在7T时显示出高达70 mM·S的横向弛豫率（₂）。这种简单的一步合成方法具有高度的通用性，能够高效地制备出所需的纳米颗粒，作为MRI造影剂具有很高的功效，并在其他生物医学应用中具有潜在的用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/b9441b81caeb/jfb-08-00046-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/5b903fd3b5b3/jfb-08-00046-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/38fe5d35ab15/jfb-08-00046-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/3a763d867be6/jfb-08-00046-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/88a1df5e1e0d/jfb-08-00046-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/b9441b81caeb/jfb-08-00046-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/5b903fd3b5b3/jfb-08-00046-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/38fe5d35ab15/jfb-08-00046-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/3a763d867be6/jfb-08-00046-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/88a1df5e1e0d/jfb-08-00046-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4b/5748553/b9441b81caeb/jfb-08-00046-g005.jpg

相似文献

[1]
Fe Core-Carbon Shell Nanoparticles as Advanced MRI Contrast Enhancer.

J Funct Biomater. 2017-10-9

[2]
Increased transverse relaxivity in ultrasmall superparamagnetic iron oxide nanoparticles used as MRI contrast agent for biomedical imaging.

Contrast Media Mol Imaging. 2016-9

[3]
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[4]
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[5]
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[6]
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J Colloid Interface Sci. 2010-1-18

[7]
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Chem Asian J. 2012-11-14

[8]
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[9]
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[10]
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引用本文的文献

[1]
Magnetic Nanoparticle Composites: Synergistic Effects and Applications.

Adv Sci (Weinh). 2021-6

[2]
Carbon Nano-Allotrope/Magnetic Nanoparticle Hybrid Nanomaterials as T2 Contrast Agents for Magnetic Resonance Imaging Applications.

J Funct Biomater. 2018-2-6

本文引用的文献

[1]
Distance-dependent magnetic resonance tuning as a versatile MRI sensing platform for biological targets.

Nat Mater. 2017-2-6

[2]
Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications.

Sci Technol Adv Mater. 2015-4-28

[3]
An efficient and highly versatile synthetic route to prepare iron oxide nanoparticles/nanocomposites with tunable morphologies.

Langmuir. 2014-9-2

[4]
High energy product developed from cobalt nanowires.

Sci Rep. 2014-6-18

[5]
Crystalline magnetic carbon nanoparticle assisted photothermal delivery into cells using CW near-infrared laser beam.

Sci Rep. 2014-5-29

[6]
Fabrication of contrast agents for magnetic resonance imaging from polymer-brush-afforded iron oxide magnetic nanoparticles prepared by surface-initiated living radical polymerization.

Biomacromolecules. 2013-9-4

[7]
Carbon-coated iron oxide nanoparticles as contrast agents in magnetic resonance imaging.

Nanoscale Res Lett. 2012-1-5

[8]
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery.

Adv Drug Deliv Rev. 2011-4-5

[9]
Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles.

Adv Mater. 2010-7-6

[10]
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.

Adv Drug Deliv Rev. 2009-11-10

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