Ramachandra Setty S, Quereshi Absar Ahmed, Viswanath Swamy A H M, Patil Tushar, Prakash T, Prabhu K, Veeran Gouda A
Department of Pharmacology, S. C. S. College of Pharmacy, Davanagere, Karnataka, India.
Fitoterapia. 2007 Dec;78(7-8):451-4. doi: 10.1016/j.fitote.2006.11.022. Epub 2007 May 10.
Hydro-ethanolic extract (70%) of Calotropis procera flowers was prepared and tested for its hepatoprotective effect against paracetamol-induced hepatitis in rats. Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, bilirubin, cholesterol, HDL and tissue GSH were tested in both treated and untreated groups. Paracetamol (2 g/kg) has enhanced the SGPT, SGOT, ALP, bilirubin and cholesterol levels and reduced the serum levels of HDL and tissue level of GSH. Treatment with hydro-ethanolic extract of C. procera flowers (200 mg/kg and 400 mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.
制备了牛角瓜花的水乙醇提取物（70%），并测试其对大鼠扑热息痛诱导的肝炎的肝保护作用。在治疗组和未治疗组中均检测了肝损伤生化标志物如SGPT、SGOT、ALP、胆红素、胆固醇、高密度脂蛋白（HDL）和组织谷胱甘肽（GSH）水平的变化。扑热息痛（2克/千克）提高了SGPT、SGOT、ALP、胆红素和胆固醇水平，并降低了HDL血清水平和GSH组织水平。用牛角瓜花水乙醇提取物（200毫克/千克和400毫克/千克）治疗已使生化标志物的改变水平以剂量依赖方式恢复到接近正常水平。
