Qureshi Absar Ahmed, Prakash T, Patil Tushar, Viswanath Swamy A H M, Gouda A Veeran, Prabhu K, Setty S Ramachandra
S. C. S. College of Pharmacy, Harapanahalli 583 131, India.
Indian J Exp Biol. 2007 Mar;45(3):304-10.
Hepatoprotective activity of 70% ethanolic extract of flowers of C. procera was studied against CCl4 induced hepatic injury in albino rats and mice. In addition, antioxidant activity was studied by in vitro models. Pre-treatment with 70% ethanolic extract (CPA) reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, bilirubin, cholesterol, HDL and tissue glutathione (GSH) levels. Similarly pretreatment with CPA reduced the CCl4 induced elevation in the pentobarbitone sleeping time. Histopathological observations also revealed that pretreatment with CPA protected the animals from CCl4 induced liver damage. CPA demonstrated dose dependant reduction in the in vitro and in vivo lipid peroxidation induced by CCl4. In addition it showed dose dependant free radical scavenging activity. The results indicate that flowers of C. procera possess hepatoprotective property possibly because of its anti-oxidant activity. This property may be attributed to the quercetin related flavonoids present in the flowers of Calotropis procera.
研究了牛角瓜花70%乙醇提取物对四氯化碳诱导的白化病大鼠和小鼠肝损伤的保肝活性。此外，通过体外模型研究了其抗氧化活性。用70%乙醇提取物（CPA）预处理可降低肝损伤的生化标志物，如血清谷丙转氨酶、血清谷草转氨酶、碱性磷酸酶、胆红素、胆固醇、高密度脂蛋白和组织谷胱甘肽（GSH）水平。同样，用CPA预处理可降低四氯化碳诱导的戊巴比妥睡眠时间延长。组织病理学观察还显示，用CPA预处理可保护动物免受四氯化碳诱导的肝损伤。CPA在体外和体内均表现出对四氯化碳诱导的脂质过氧化的剂量依赖性降低。此外，它还表现出剂量依赖性的自由基清除活性。结果表明，牛角瓜花具有保肝特性，可能是由于其抗氧化活性。这种特性可能归因于牛角瓜花中存在的与槲皮素相关的黄酮类化合物。
