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[成年人群体中的脊髓灰质炎群体免疫力及其对根除该感染的影响]

[Collective poliomyelitis immunity in the adult population and its impact on eradication of this infection].

作者信息

Seĭbil' V B, Malyshkina L P, Lavrova I K, Efimova V F

出版信息

Vopr Virusol. 2007 May-Jun;52(3):44-7.

Abstract

Collective poliomyelitis immunity was studied in 6339 donors from 19 towns and cities of Russia. Its stress substantially varied in different towns and cities. Studies of strain-specific antibodies to vaccine and wild viruses of poliomyelitis in donors from 4 towns established that the immune persons were more in the town where wild polioviruses had previously circulated than in those where the circulation of wild polioviruses had been limited and immunity resulted from vaccination. Circulation of vaccine viruses and reversion of their neurovirulent properties should be expected in the town where there are low collective poliomyelitis immunity rates. It is concluded that it is impossible to eradicate poliomyelitis as infection today; it is possible only to eliminate the disease if further vaccination of children is performed with live poliomyelitis vaccine.

摘要

对来自俄罗斯19个城镇的6339名献血者的群体脊髓灰质炎免疫力进行了研究。其应激反应在不同城镇有很大差异。对来自4个城镇的献血者针对脊髓灰质炎疫苗病毒和野生病毒的毒株特异性抗体的研究表明,与野生脊髓灰质炎病毒传播受限且免疫力来自疫苗接种的城镇相比,野生脊髓灰质炎病毒此前曾传播的城镇中免疫者更多。在群体脊髓灰质炎免疫率较低的城镇,应预计疫苗病毒的传播及其神经毒力特性的逆转。得出的结论是,如今不可能根除脊髓灰质炎感染;只有通过继续给儿童接种口服脊髓灰质炎活疫苗,才有可能消除该疾病。

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