慢性日光性视网膜病变的光学相干断层扫描和多焦视网膜电图检查结果
Optical coherence tomography and multifocal electroretinogram findings in chronic solar retinopathy.
作者信息
Stangos Alexandros N, Petropoulos Ioannis K, Pournaras Jean-Antoine C, Zaninetti Marc, Borruat François-Xavier, Pournaras Constantin J
机构信息
Division of Ophthalmology, Department of Clinical Neurosciences, University Hospitals of Geneva, Geneva, Switzerland.
出版信息
Am J Ophthalmol. 2007 Jul;144(1):131-4. doi: 10.1016/j.ajo.2007.03.003.
PURPOSE
To correlate the structural and functional retinal defects, which are induced photochemically in chronic solar retinopathy.
DESIGN
Observational case report.
METHODS
Four emmetropic eyes of two patients, previously diagnosed with chronic solar retinopathy, were evaluated by optical coherence tomography (OCT), multifocal electroretinography, and fluorescein angiography.
RESULTS
Visual acuity ranged from 20/80 to 20/50 and all subjects had central and steady fixation. In all eyes, OCT demonstrated a hyporeflective space at the level of outer retinal and retinal pigment epithelium (RPE) layers, which was limited to the fovea. The foveal contour was preserved with normal vitreoretinal interface. Multifocal electroretinogram (mfERG) trace array of the first-order kernel demonstrated attenuated responses extending to a larger area, the para- and perifovea. A foveal RPE window defect was angiographically evident in all cases.
CONCLUSIONS
A model of centrifugal neuronal damage is proposed for chronic solar retinopathy, with more functional than structural neuroretinal defects.
目的
关联慢性日光性视网膜病变中光化学诱导的视网膜结构和功能缺陷。
设计
观察性病例报告。
方法
通过光学相干断层扫描（OCT）、多焦视网膜电图和荧光素血管造影对两名先前被诊断为慢性日光性视网膜病变患者的四只正视眼进行评估。
结果
视力范围为20/80至20/50，所有受试者均有中心且稳定的注视。在所有眼中，OCT显示在外视网膜和视网膜色素上皮（RPE）层水平存在低反射间隙，该间隙局限于黄斑中心凹。黄斑中心凹轮廓保留，玻璃体视网膜界面正常。一阶核的多焦视网膜电图（mfERG）迹线阵列显示反应减弱，延伸至更大区域，即黄斑旁和黄斑周边。所有病例中均可见黄斑中心凹RPE窗缺损。
结论
提出了一种用于慢性日光性视网膜病变的离心性神经元损伤模型，其中功能性神经视网膜缺陷多于结构性缺陷。
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