Physical properties of tissues relevant to arterial ultrasound imaging and blood velocity measurement.

A review was undertaken of physical phenomena and the values of associated physical quantities relevant to arterial ultrasound imaging and measurement. Arteries are multilayered anisotropic structures. However, the requirement to obtain elasticity measurements from the data available using ultrasound imaging necessitates the use of highly simplified constitutive models involving Young's modulus, E. Values of E are reported for healthy arteries and for the constituents of diseased arteries. It is widely assumed that arterial blood flow is Newtonian. However, recent studies suggest that non-Newtonian behavior has a strong influence on arterial flow, and the balance of published evidence suggests that non-Newtonian behavior is associated primarily with red cell deformation rather than with aggregation. Hence, modeling studies should account for red cell deformation and the shear thinning effect that this produces. Published literature in healthy adults gives an average hematocrit and high-shear viscosity of 0.44 +/- 0.03 and 3.9 +/- 0.6 mPa.s, respectively. Published data on the acoustic properties of arteries and blood is sufficiently consistent between papers to allow compilation and derivation of best-fit equations summarizing the behavior across a wide frequency range, which then may be used in future modeling studies. Best-fit equations were derived for the attenuation coefficient vs. frequency in whole arteries (R(2) = 0.995), plasma (R(2) = 0.963) and blood with hematocrit near 45% (R(2) = 0.999), and for the backscatter coefficient vs. frequency from blood with hematocrit near 45% (R(2) = 0.958).